Selective association of lipid-rich R-like lipopolysaccharide subunits with murine spleen cells.
Selective association of lipid-rich R-like lipopolysaccharide subunits with murine spleen cells.
复制标题
富含脂质的 R 样脂多糖亚基与小鼠脾细胞的选择性关联。
DOI：
10.1016/0161-5890(84)90021-x
复制
发表时间：
1984
影响因子：
3.6
通讯作者：
Morrison,DC
中科院分区：
文献类型：
--
作者：
Goodman,SA;Morrison,DC
SDS-PAGE was used to analyze the subunit composition of 125 I-lipopolysaccharide (LPS) in the cell-associated and supernatant fractions of murine spleen cells after culture with radiolabeled LPS from the smooth strain of E. coli 055: B5. Quantitative estimates from densitometric scans of autoradiographs indicated that certain R-like subunits were selectively enriched in cell-associated fractions by a factor of 2.8 as compared to native 055 LPS. Coincident with this selective enrichment was a 57% decrease in these subunits in supernatant fractions. In contrast, the level of polysaccharide-containing subunits in cell-associated fractions was equivalent to or less than the corresponding subunit in native LPS. LPS bound at 37° C was capable of eliciting a significant B-lymphocyte proliferative response in responder spleen cells. However, this selective binding of lipid-rich R-like subunits to splenocytes is insufficient, by itself, to initiate a triggering event since it is both quantitatively and qualititatively indistinguishable in lymphoid cells from the LPS responder (C3HeB FeJ) mouse and the LPS non-responder (C3H HeJ) mouse.
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