Monkeypox virus emerges from the shadow of its more infamous cousin: family biology matters.

Monkeypox virus emerges from the shadow of its more infamous cousin: family biology matters.
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DOI:
10.1080/22221751.2022.2095309
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发表时间:
2022-12
影响因子:
13.2
通讯作者:
--
中科院分区:
医学2区
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--
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猴痘病毒(MPXV)与臭名昭著的天花病毒密切相关,导致人类发热性皮疹疾病,类似于天花,但比天花温和。在20世纪,人类猴痘主要是一种罕见的人畜共患疾病,仅限于西非和中非的森林地区。然而,在本世纪,随着全球人群中天花疫苗诱导的免疫力的减弱,病例数量和地理范围显著增加。自2022年5月以来,人类猴痘在多个国家爆发,其病例数量之多以及与流行国家没有直接联系是不寻常的,这引发了人们对猴痘传播模式可能发生变化的担忧,这可能会构成更大的全球威胁。在这里,我们回顾了MPXV生物学的风险评估和准备猴痘流行病相关的方面,重点是在了解病毒宿主范围,进化潜力和中和目标的最新进展。
Monkeypox virus (MPXV) is closely related to the infamous variola (smallpox) virus, causing a febrile rash illness in humans similar to but milder than smallpox. In the twentieth century, human monkeypox had been mostly a rare zoonotic disease confined to forested areas in West and Central Africa. However, the case number and geographic range have increased significantly in this century, coincided with the waning of the smallpox vaccine-induced immunity in the global population. The outbreak of human monkeypox in multiple countries since May 2022 has been unusual in its large case number and the absence of direct links to endemic countries, raising concerns for a possible change in monkeypox transmission pattern that could pose a greater global threat. Here, we review aspects of MPXV biology that are relevant for risk assessment and preparedness for a monkeypox epidemic, with an emphasis on recent progress in understanding of the virus host range, evolutionary potential, and neutralization targets.
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发表时间: 2022
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