The acute toxicity and hematological characterization of the effects of tentacle-only extract from the jellyfish Cyanea capillata.
The acute toxicity and hematological characterization of the effects of tentacle-only extract from the jellyfish Cyanea capillata.
复制标题
海蜇水母触手提取物的急性毒性和血液学特征
作者：
Xiao L;Liu S;He Q;Wang Q;Ye X;Liu G;Nie F;Zhao J;Zhang L
To investigate the hematologic changes and the activities of jellyfish venoms other than hemolytic and cardiovascular toxicities, the acute toxicity of tentacle-only extract (TOE) from the jellyfish Cyanea capillata was observed in mice, and hematological indexes were examined in rats. The median lethal dose (LD50) of TOE was 4.25 mg/kg, and the acute toxicity involved both heart- and nervous system-related symptoms. Arterial blood gas indexes, including pH, PCO2, HCO3−, HCO3std, TCO2, BEecf and BE (B), decreased significantly. PO2 showed a slight increase, while SO2c (%) had no change at any time. Na+ and Ca2+ decreased, but K+ increased. Biochemical indexes, including LDH, CK, CK-MB, ALT, AST and sCr, significantly increased. Other biochemical indexes, including BUN and hemodiastase, remained normal. Lactic acid significantly increased, while glucose, Hct% and THbc showed slight temporary increases and then returned to normal. These results on the acute toxicity and hematological changes should improve our understanding of the in vivo pathophysiological effects of TOE from C. capillata and indicate that it may also have neurotoxicity, liver toxicity and muscular toxicity in addition to hemolytic and cardiovascular toxicities, but no kidney or pancreatic toxicity.
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影响因子：
2.8
作者：
Edwards, LP;Whitter, E;Hessinger, DA
通讯作者：
Hessinger, DA
影响因子：
8.8
作者：
El-Sayed, Yasser Said;Khalil, Riad Hassan;Saad, Talaat Talaat
通讯作者：
Saad, Talaat Talaat
影响因子：
2.8
作者：
Edwards, L;Hessinger, DA
通讯作者：
Hessinger, DA
影响因子：
2.8
作者：
Tibballs, James
通讯作者：
Tibballs, James
影响因子：
3.5
作者：
Winter, Kelly L.;Isbister, Geoffrey K.;Hodgson, Wayne C.
通讯作者：
Hodgson, Wayne C.