Midlife obesity and trajectories of brain volume changes in older adults.
Midlife obesity and trajectories of brain volume changes in older adults.
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DOI：
10.1002/hbm.21353
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发表时间：
2012-09
影响因子：
4.8
通讯作者：
Resnick, Susan M.
中科院分区：
文献类型：
--
作者：
Driscoll, Ira;Beydoun, May A.;An, Yang;Davatzikos, Christos;Ferrucci, Luigi;Zonderman, Alan B.;Resnick, Susan M.
虽然肥胖与大脑结构变化有关，但人们对其与脑萎缩率的关系知之甚少。我们在巴尔的摩老龄化纵向研究中前瞻性随访的152名个体（年龄= 69±7.8）中，研究了整体（BMI）和中心（腰围）中年肥胖与随后的局部脑萎缩轨迹之间的关系; 21名个体在随访期间受损。我们报告在非痴呆的老年个体中，在年龄相关性萎缩的背景下，整体或中心性中年肥胖与随后的局部脑体积变化率之间没有关联（P> 0.05）。当观察整个样本时，观察到整体肥胖者的灰质、楔前叶、扣带回和眶额回体积下降更大（P < 0.03），即使分析中仅包括痴呆诊断点的数据（即，但仍被认为是临床上正常的）。此外，当在BMI和腰围值的范围内检查区域体积变化的轨迹时，而不是采用截止点来定义肥胖时，出现了不同的结果模式。总体而言，我们的研究结果表明，中年肥胖可能是发展认知障碍和痴呆症的个体脑萎缩的重要调节剂，而它对非痴呆老年人的结构性大脑完整性几乎没有影响。此外，研究结果之间的差异可能部分是由于参与者抽样和方法上的差异。
Although obesity has been linked to structural brain changes, little is known about its associations with the rates of brain atrophy. We examined associations between global (BMI) and central (waist circumference) midlife obesity and subsequent trajectories of regional brain atrophy in 152 individuals (M (age) = 69±7.8) prospectively followed through the Baltimore Longitudinal Study of Aging; 21 individuals became impaired during follow-up. We report no associations (P’s > 0.05) between either global or central midlife obesity and subsequent rates of regional brain volume changes against a background of age-related atrophy in older individuals who remained non-demented. When looking at the entire sample, greater decline was observed in the volume of gray matter, precuneus, cingulate and orbito-frontal gyri for globally obese (P’s < 0.03), even though only data up to the point of dementia diagnosis were included in the analyses (i.e., while still considered clinically normal). Moreover, when trajectories of regional volume changes were examined across the range of BMI and waist circumference values instead of employing a cut-off point to define obesity, a different pattern of results emerged. Overall, our results suggest that midlife obesity may be an important modifier of brain atrophy in individuals who are developing cognitive impairment and dementia, while it has little effect on structural brain integrity in non-demented older adults. Moreover, the discrepancies in findings between studies may be in part due to participant sampling and methodological differences.
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影响因子：
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作者：
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通讯作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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