Animal infection models using non-mammals.

Animal infection models using non-mammals.
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动物感染模型使用非哺乳动物。

DOI:
10.1111/1348-0421.12834
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发表时间:
2020-09
影响因子:
2.6
通讯作者:
Furuta K
Furuta K
中科院分区:
医学4区
文献类型:
--
作者:
Kaito C;Murakami K;Imai L;Furuta K

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使用非人类动物模型进行感染实验对于在分子水平上研究人类致病菌的感染过程具有重要意义。哺乳动物,如老鼠和兔子,也被用作动物感染模型,但这些实验需要大量的动物,这是昂贵的,而且充满了伦理问题。各种非哺乳动物感染模型已被用于研究各种人类致病菌的分子机制,包括金黄色葡萄球菌、化脓性链球菌和铜绿假单胞菌。本文讨论了非哺乳动物感染模型的理想特征,并描述了最近利用秀丽隐杆线虫、蚕、果蝇、斑马鱼、斑点蟋蟀、角虫和蜡虫的非哺乳动物感染模型。
The use of non‐human animal models for infection experiments is important for investigating the infectious processes of human pathogenic bacteria at the molecular level. Mammals, such as mice and rabbits, are also utilized as animal infection models, but large numbers of animals are needed for these experiments, which is costly, and fraught with ethical issues. Various non‐mammalian animal infection models have been used to investigate the molecular mechanisms of various human pathogenic bacteria, including Staphylococcus aureus, Streptococcus pyogenes, and Pseudomonas aeruginosa. This review discusses the desirable characteristics of non‐mammalian infection models and describes recent non‐mammalian infection models that utilize Caenorhabditis elegans, silkworm, fruit fly, zebrafish, two‐spotted cricket, hornworm, and waxworm.
DOI: 10.3389/fcimb.2017.00099
发表时间: 2017-03-28
影响因子: 5.7
作者:
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