Edible bird's nest extract inhibits influenza virus infection.

Edible bird's nest extract inhibits influenza virus infection.
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DOI:
10.1016/j.antiviral.2006.02.005
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发表时间:
2006-07
期刊:
影响因子:
7.6
通讯作者:
Suzuki Y
Suzuki Y
中科院分区:
医学2区
文献类型:
--
作者:
Guo CT;Takahashi T;Bukawa W;Takahashi N;Yagi H;Kato K;Hidari KI;Miyamoto D;Suzuki T;Suzuki Y

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可食燕窝(EBN)是由其唾液制成的燕窝。虽然EBN已被广泛用于增强免疫能力,但其抗病毒功效尚未得到详细研究。经胰酶水解后,我们发现EBN提取物对流感病毒的感染具有较强的抑制作用,且与宿主范围无关。Western blotting实验表明,EBN提取物与流感病毒结合。EBN提取物能中和流感病毒对MDCK细胞的感染,抑制流感病毒对红细胞的血凝,但不能抑制流感病毒唾液酸酶的活性。荧光高效液相色谱法表明,EBN中唾液酸的主要分子种类为n -乙酰神经氨酸。结果表明,EBN是一种安全有效的预防流感病毒的天然来源。
Edible bird's nest (EBN) is the nest of the swift that is made from its saliva. Although EBN has been widely used for enhancing immunocompetence, its antiviral efficacy has not been studied in detail. We found that EBN extract could strongly inhibit infection with influenza viruses in a host range-independent manner when it was hydrolyzed with Pancreatin F. Western blotting assay showed that the EBN extract bound to influenza virus. Furthermore, EBN extract could neutralize the infection of MDCK cells with influenza viruses and inhibit hemagglutination of influenza viruses to erythrocytes, but it could not inhibit the activity of influenza virus sialidase. Fluorometric HPLC indicated that the major molecular species of sialic acid in EBN is N-acetylneuraminic acid. The results suggest that EBN is a safe and valid natural source for the prevention of influenza viruses.
DOI: 10.1016/s0014-5793(97)00127-0
发表时间: 1997-03-10
期刊: FEBS LETTERS
影响因子: 3.5
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