Periostin: its role in asthma and its potential as a diagnostic or therapeutic target.
Periostin: its role in asthma and its potential as a diagnostic or therapeutic target.
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骨膜素：其在哮喘中的作用及其作为诊断或治疗靶点的潜力。
DOI：
10.1186/s12931-015-0218-2
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发表时间：
2015-05-17
影响因子：
5.8
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Li W;Gao P;Zhi Y;Xu W;Wu Y;Yin J;Zhang J
越来越多的证据表明，骨膜蛋白（一种基质细胞蛋白）参与许多基本的生物过程，例如细胞增殖、细胞侵袭和血管生成。骨膜素表达的变化通常在各种癌症和癌前病变中检测到，并且骨膜素可能参与调节多种癌细胞活性，从而促进肿瘤发生、癌症进展和转移。 Periostin 还被证明参与过敏性炎症的许多方面，例如嗜酸性粒细胞募集、气道重塑、Th2 表型的发展以及炎症介质表达的增加。在体内模型中，与对照小鼠的支气管肺泡灌洗液 (BAL) 样本相比，从卵清蛋白攻击的小鼠中获得的支气管肺泡灌洗 (BAL) 液中的骨膜素含量明显更高。迄今为止，骨膜素与人类哮喘相关的分子机制尚未完全阐明。本综述将重点关注骨膜素的已知情况及其在介导哮喘的病理生理机制中的作用，以评估骨膜素分别作为检测和治疗哮喘的生物标志物和治疗靶点的潜力。
Accumulating evidence shows that periostin, a matricellular protein, is involved in many fundamental biological processes such as cell proliferation, cell invasion, and angiogenesis. Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating a diverse set of cancer cell activities that contribute to tumorigenesis, cancer progression, and metastasis. Periostin has also been shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype, and increased expression of inflammatory mediators. In an in vivo model, bronchoalveolar lavage (BAL) fluid obtained from ovalbumin-challenged mice was found to contain significantly higher levels of periostin compared to BAL samples from control mice. To date, the molecular mechanisms involving periostin in relation to asthma in humans have not been fully elucidated. This review will focus on what is known about periostin and its role in the pathophysiological mechanisms that mediate asthma in order to evaluate the potential for periostin to serve as a biomarker and therapeutic target for the detection and treatment of asthma, respectively.
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DOI：
10.1016/j.alit.2014.06.001
发表时间：
2015-01
期刊：
Allergology international : official journal of the Japanese Society of Allergology
影响因子：
--
作者：
Arima K;Ohta S;Takagi A;Shiraishi H;Masuoka M;Ontsuka K;Suto H;Suzuki S;Yamamoto K;Ogawa M;Simmons O;Yamaguchi Y;Toda S;Aihara M;Conway SJ;Ikeda S;Izuhara K
通讯作者：
Izuhara K
影响因子：
12.4
作者：
Bobolea, I.;Barranco, P.;Quirce, S.
通讯作者：
Quirce, S.
影响因子：
15.9
作者：
Hakuno, Daihiko;Kimura, Naritaka;Fukuda, Keiichi
通讯作者：
Fukuda, Keiichi
影响因子：
2.9
作者：
Hong LZ;Wei XW;Chen JF;Shi Y
通讯作者：
Shi Y
影响因子：
8
作者：
Conway, Simon J.;Izuhara, Kenji;Kudo, Yasusei;Litvin, Judith;Markwald, Roger;Ouyang, Gaoliang;Arron, Joseph R.;Holweg, Cecile T. J.;Kudo, Akira
通讯作者：
Kudo, Akira