The role of periostin in tissue remodeling across health and disease.
The role of periostin in tissue remodeling across health and disease.
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DOI：
10.1007/s00018-013-1494-y
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发表时间：
2014-04
影响因子：
8
通讯作者：
Kudo, Akira
中科院分区：
文献类型：
--
作者：
Conway, Simon J.;Izuhara, Kenji;Kudo, Yasusei;Litvin, Judith;Markwald, Roger;Ouyang, Gaoliang;Arron, Joseph R.;Holweg, Cecile T. J.;Kudo, Akira
Periostin，也称为成骨细胞特异性因子2，是一种基质细胞蛋白，在骨科、组织修复、肿瘤学、心血管和呼吸系统以及各种炎症环境中具有已知的功能。然而，到目前为止，大多数研究都是在不同的和有限的领域进行的，这意味着对这种有趣的分子的整体理解仍然是支离破碎的。在这里，我们整合了关于Periostin表达的现有证据，它在发育中的正常作用，以及它在病理修复、再生和疾病中是否发挥类似的功能，以便将正在进行的Periostin研究的不同研究领域结合在一起。尽管Periostin在健康和疾病中似乎扮演着不同的角色，但作为对侮辱/损伤的反应的组织重塑正在成为这种基质细胞分子的共同功能分母。Periostin在细胞命运改变过程中瞬时上调，无论是生理的还是病理的。结合不同条件的观察，可以提出一个共同的事件模式，包括Periostin在发育过程中的定位、损伤和损伤、上皮-间充质转化、细胞外基质重组和重塑。我们认为间充质重塑是基质细胞蛋白Periostin在生理和疾病中的主导作用。Periostin可能被视为一种重要的结构介体，在对侮辱/损伤的反应中平衡适当和不适当的组织适应。
Periostin, also termed osteoblast-specific factor 2, is a matricellular protein with known functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and in various inflammatory settings. However, most of the research to date has been conducted in divergent and circumscribed areas meaning that the overall understanding of this intriguing molecule remains fragmented. Here, we integrate the available evidence on periostin expression, its normal role in development, and whether it plays a similar function during pathologic repair, regeneration, and disease in order to bring together the different research fields in which periostin investigations are ongoing. In spite of the seemingly disparate roles of periostin in health and disease, tissue remodeling as a response to insult/injury is emerging as a common functional denominator of this matricellular molecule. Periostin is transiently upregulated during cell fate changes, either physiologic or pathologic. Combining observations from various conditions, a common pattern of events can be suggested, including periostin localization during development, insult and injury, epithelial–mesenchymal transition, extracellular matrix restructuring, and remodeling. We propose mesenchymal remodeling as an overarching role for the matricellular protein periostin, across physiology and disease. Periostin may be seen as an important structural mediator, balancing appropriate versus inappropriate tissue adaption in response to insult/injury.
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影响因子：
7.8
作者：
Elkins, T;Hortsch, M;Bieber, A J;Snow, P M;Goodman, C S
通讯作者：
Goodman, C S
DOI：
10.1161/atvbaha.111.224352
发表时间：
2011-07
期刊：
Arteriosclerosis, thrombosis, and vascular biology
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作者：
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影响因子：
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作者：
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作者：
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通讯作者：
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