Neurogenic Flare Response following Image-Guided Focused Ultrasound in the Mouse Peripheral Nervous System in Vivo.
Neurogenic Flare Response following Image-Guided Focused Ultrasound in the Mouse Peripheral Nervous System in Vivo.
复制标题
图像引导聚焦超声在小鼠体内外周神经系统中的神经原性耀斑反应。
DOI：
10.1016/j.ultrasmedbio.2021.04.030
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发表时间：
2021-09
影响因子：
2.9
通讯作者：
Konofagou EE
中科院分区：
文献类型：
--
作者：
Kim MG;Kamimura HAS;Konofagou EE
Focused ultrasound (FUS) has been used to noninvasively elicit or inhibit motor neuronal activity in the mouse peripheral nervous system in vivo. However, less is known about whether FUS elicits immune system responses associated with peripheral sensory neuronal activity. In this study, we demonstrate that non-invasive ultrasound image-guided FUS can elicit the neurogenic axon reflex of peripheral nerves in the mouse sciatic nerve. The local vasodilation in the plantar view of the hind paw detected by a high-resolution laser Doppler imager indicated neurogenic flare responses following FUS stimulation. The effects of FUS were compared with control groups, where a distinct pattern of blood flow changes was only observed in FUS-elicited neurogenic flare responses. The findings indicate that image-guided FUS elicits local axon reflexes in vivo with a high degree of specificity and penetration depth.
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影响因子：
2.9
作者：
MIHRAN, RT;BARNES, FS;WACHTEL, H
通讯作者：
WACHTEL, H
影响因子：
16.2
作者：
Talbot S;Abdulnour RE;Burkett PR;Lee S;Cronin SJ;Pascal MA;Laedermann C;Foster SL;Tran JV;Lai N;Chiu IM;Ghasemlou N;DiBiase M;Roberson D;Von Hehn C;Agac B;Haworth O;Seki H;Penninger JM;Kuchroo VK;Bean BP;Levy BD;Woolf CJ
通讯作者：
Woolf CJ
影响因子：
7.7
作者：
Krämer, HH;Schmelz, M;Bickel, A
通讯作者：
Bickel, A
影响因子：
2.5
作者：
MAGERL, W;SZOLCSANYI, J;HANDWERKER, HO
通讯作者：
HANDWERKER, HO
影响因子：
3.7
作者：
Hovaguimian, Alexandra;Gibbons, Christopher H.
通讯作者：
Gibbons, Christopher H.