Prevalence and Characteristics of Myopic Degeneration in an Adult Chinese American Population: The Chinese American Eye Study.
Prevalence and Characteristics of Myopic Degeneration in an Adult Chinese American Population: The Chinese American Eye Study.
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DOI：
10.1016/j.ajo.2017.12.010
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发表时间：
2018-03
影响因子：
4.2
通讯作者：
Chinese American Eye Study Group
中科院分区：
文献类型：
--
作者：
Choudhury F;Meuer SM;Klein R;Wang D;Torres M;Jiang X;McKean-Cowdin R;Varma R;Chinese American Eye Study Group
旨在描述并提供基于人群的华裔美国人近视退化 (MD) 患病率估计，华裔美国人是过去十年美国增长最快的少数族裔人口。基于人群的横断面研究。居住在加利福尼亚州蒙特利公园市的 1523 名 50 岁及以上患有近视的华裔美国成年人接受了访谈和全面的眼科检查，包括主客观验光以及立体眼底摄影。对于每位参与者，近视屈光不正最严重的眼睛都包含在该分析中。 MD 由专家分级员以隐蔽方式进行评估。根据继发于近视的任何退行性病变的存在，近视患者中任何 MD 的患病率为 44.9%。当 MD 通过病理性近视荟萃分析的修改版本定义时，患病率为 32.2%。特定病变的发生率包括：棋盘状花纹（31.7%）、倾斜椎间盘（28.1%）、乳头周围萎缩（7.0%）、葡萄肿（5.7%）、弥漫性萎缩（6.4%）、漆裂纹（2.6%）、脉络膜内空洞（2.2%）、斑片状萎缩（0.9%）和终末期MD（0.2%）。 MD 的患病率在老年近视患者以及近视较严重和眼轴较长的参与者中较高 (p < .001)。这些数据首次基于人群对华裔美国人的 MD 进行了估计，并表明很大比例的华裔美国人可能面临患 MD 和相关视力并发症的风险。这组华裔美国人中的 MD 患病率高于其他东亚人群和其他种族人群中观察到的患病率。
To characterize and provide population-based prevalence estimates of myopic degeneration (MD) among Chinese Americans, the fastest growing minority population in the United States in the last decade. Population-based, cross-sectional study. 1523 Chinese American adults with myopia, aged 50 years and older, residing in the City of Monterey Park, California, underwent an interview and comprehensive eye exam, including subjective and objective refraction, and stereoscopic fundus photography. For each participant, the eye with the worse myopic refractive error was included in this analysis. MD was assessed in a masked manner by an expert grader. The prevalence of any MD was 44.9% among myopes based on the presence of any degenerative lesion secondary to myopia. The prevalence was 32.2% when MD was defined by a modified version of the Meta-Analysis for Pathologic Myopia. The prevalence of specific lesions included: tessellation (31.7%), tilted disc (28.1%), peripapillary atrophy (7.0%), staphyloma (5.7%), diffuse atrophy (6.4%), lacquer cracks (2.6%), intrachoroidal cavitation (2.2%), patchy atrophy (0.9%), and end-stage MD (0.2%). The prevalence of MD was higher among older myopes, and among participants with more severe myopia and longer axial length (p < .001). These data provide the first population-based estimates of MD in Chinese Americans and indicate that a high proportion of Chinese Americans might be at risk for MD and associated visual complications. Prevalence of MD in this cohort of Chinese Americans was higher than that observed in other East Asian populations, and in people of other ethnicities.
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