A Genome-Wide Test of the Differential Susceptibility Hypothesis Reveals a Genetic Predictor of Differential Response to Psychological Treatments for Child Anxiety Disorders.
A Genome-Wide Test of the Differential Susceptibility Hypothesis Reveals a Genetic Predictor of Differential Response to Psychological Treatments for Child Anxiety Disorders.
复制标题
对差异易感性假设的全基因组检验揭示了对儿童焦虑症的心理治疗反应的遗传预测指标。
DOI：
10.1159/000444023
复制
发表时间：
2016
影响因子：
22.8
通讯作者：
Eley TC
中科院分区：
文献类型：
--
作者：
Keers R;Coleman JR;Lester KJ;Roberts S;Breen G;Thastum M;Bögels S;Schneider S;Heiervang E;Meiser-Stedman R;Nauta M;Creswell C;Thirlwall K;Rapee RM;Hudson JL;Lewis C;Plomin R;Eley TC
差异易感性假说表明，某些基因变异会缓和积极和消极环境对心理健康的影响，因此可能是心理治疗反应的重要预测因子。然而，到目前为止，对这些变异的鉴定仅限于预先选择的候选基因。在这项研究中，我们将差异易感性假设从候选基因扩展到全基因组方法，以测试环境敏感度的多基因评分是否可以预测焦虑症儿童对认知行为治疗(CBT)的反应。我们使用一种新的方法确定了与环境敏感性相关的变异，在该方法中，我们检查了1026对同卵双胞胎中情绪问题的对内变异性作为对基因的函数。我们根据全基因组的研究结果创建了环境敏感性的多基因评分，并测试了该评分作为1,406名儿童情绪问题父母教养方式的调节变量，以及对973名患有焦虑症的儿童进行个人、群体和简短的父母主导的CBT反应的调节因子。多基因得分显著缓和了父母教养对情绪问题的影响和治疗的效果。得分高的个体对单项CBT的反应明显好于团体CBT或简明父母主导的CBT(缓解率分别为70.9、55.5和41.6%)。在成功复制之前，我们的结果应该被认为是探索性的。然而，如果重复，他们表明，对环境最敏感的人可能更有可能在不利的环境中出现情绪问题，但也会从最密集的治疗类型中受益更多。
The differential susceptibly hypothesis suggests that certain genetic variants moderate the effects of both negative and positive environments on mental health and may therefore be important predictors of response to psychological treatments. Nevertheless, the identification of such variants has so far been limited to preselected candidate genes. In this study we extended the differential susceptibility hypothesis from a candidate gene to a genome-wide approach to test whether a polygenic score of environmental sensitivity predicted response to cognitive behavioural therapy (CBT) in children with anxiety disorders. We identified variants associated with environmental sensitivity using a novel method in which within-pair variability in emotional problems in 1,026 monozygotic twin pairs was examined as a function of the pairs' genotype. We created a polygenic score of environmental sensitivity based on the whole-genome findings and tested the score as a moderator of parenting on emotional problems in 1,406 children and response to individual, group and brief parent-led CBT in 973 children with anxiety disorders. The polygenic score significantly moderated the effects of parenting on emotional problems and the effects of treatment. Individuals with a high score responded significantly better to individual CBT than group CBT or brief parent-led CBT (remission rates: 70.9, 55.5 and 41.6%, respectively). Pending successful replication, our results should be considered exploratory. Nevertheless, if replicated, they suggest that individuals with the greatest environmental sensitivity may be more likely to develop emotional problems in adverse environments but also benefit more from the most intensive types of treatment.
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DOI：
10.1192/bjp.bp.115.168229
发表时间：
2016-09
期刊：
The British journal of psychiatry : the journal of mental science
影响因子：
--
作者：
Coleman JR;Lester KJ;Keers R;Roberts S;Curtis C;Arendt K;Bögels S;Cooper P;Creswell C;Dalgleish T;Hartman CA;Heiervang ER;Hötzel K;Hudson JL;In-Albon T;Lavallee K;Lyneham HJ;Marin CE;Meiser-Stedman R;Morris T;Nauta MH;Rapee RM;Schneider S;Schneider SC;Silverman WK;Thastum M;Thirlwall K;Waite P;Wergeland GJ;Breen G;Eley TC
通讯作者：
Eley TC
DOI：
10.1016/j.jaac.2015.03.018
发表时间：
2015-06
影响因子：
13.3
作者：
Hudson, Jennifer L.;Keers, Robert;Roberts, Susanna;Coleman, Jonathan R. I.;Breen, Gerome;Arendt, Kristian;Boegels, Susan;Cooper, Peter;Creswell, Cathy;Hartman, Catharina;Heiervang, Einar R.;Hoetzel, Katrin;In-Albon, Tina;Lavallee, Kristen;Lyne-Ham, Heidi J.;Marin, Carla E.;McKinnon, Anna;Meiser-Stedman, Richard;Morris, Talia;Nauta, Maaike;Rapee, Ronald M.;Schneider, Silvia;Schneider, Sophie C.;Silverman, Wendy K.;Thastum, Mikael;Thirlwall, Kerstin;Waite, Polly;Wergeland, Gro Janne;Lester, Kathryn J.;Eley, Thalia C.
通讯作者：
Eley, Thalia C.
影响因子：
3.3
作者：
Deater-Deckard, K;Dodge, KA;Pettit, GS
通讯作者：
Pettit, GS
影响因子：
6.8
作者：
Hankin BL;Nederhof E;Oppenheimer CW;Jenness J;Young JF;Abela JR;Smolen A;Ormel J;Oldehinkel AJ
通讯作者：
Oldehinkel AJ
影响因子：
3.7
作者：
Manceau V;Kremmer E;Nabel EG;Maucuer A
通讯作者：
Maucuer A