Differential susceptibility in youth: evidence that 5-HTTLPR x positive parenting is associated with positive affect 'for better and worse'.
Differential susceptibility in youth: evidence that 5-HTTLPR x positive parenting is associated with positive affect 'for better and worse'.
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DOI：
10.1038/tp.2011.44
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发表时间：
2011-10-04
影响因子：
6.8
通讯作者：
Oldehinkel AJ
中科院分区：
文献类型：
--
作者：
Hankin BL;Nederhof E;Oppenheimer CW;Jenness J;Young JF;Abela JR;Smolen A;Ormel J;Oldehinkel AJ
积极情感与各种精神障碍的现象学经历、发展精神病理学的脆弱性和整体社会情感功能有关。然而，发展的影响，可能有助于积极的影响已经研究不足。本研究通过对青少年5-HTTLPR基因型和养育环境（积极和支持性父母教养的程度）的研究，探讨了差异易感性假说（DSH），即携带5-HTTLPR短等位基因的青少年对支持性和非支持性父母教养的影响和反应更大，分别表现出更高和更低的积极情感。三项独立研究在儿童和青少年（年龄范围9-15岁;总N=1874）中测试了这种基因-环境相互作用（GxE）。在研究1（N=307; 54%的女孩）中，通过父母报告评估了积极/支持的养育方式，在研究2（N=197; 58%的女孩）中，通过实验室中亲子互动的编码观察，在研究3（N=1370; 53%的女孩）中，通过自我报告评估了积极/支持的养育方式。所有三项研究的结果表明，5-HTTLPR的功能性短等位基因纯合子的青年更响应养育环境背景下的“更好和更坏”的方式。具体而言，遗传易感青年（即S'S '组）谁经历了不支持，非积极的父母表现出低水平的积极影响，而更高水平的积极影响的遗传易感青年的支持和积极的父母条件下。这些GxE结果与DSH一致，并可能为专注于积极情绪，养育和遗传易感性的发育精神病理学的病因模型和干预提供信息。
Positive affect has been implicated in the phenomenological experience of various psychiatric disorders, vulnerability to develop psychopathology and overall socio-emotional functioning. However, developmental influences that may contribute to positive affect have been understudied. Here, we studied youths' 5-HTTLPR genotype and rearing environment (degree of positive and supportive parenting) to investigate the differential susceptibility hypothesis (DSH) that youth carrying short alleles of 5-HTTLPR would be more influenced and responsive to supportive and unsupportive parenting, and would exhibit higher and lower positive affect, respectively. Three independent studies tested this gene–environment interaction (GxE) in children and adolescents (age range 9–15 years; total N=1874). In study 1 (N=307; 54% girls), positive/supportive parenting was assessed via parent report, in study 2 (N=197; 58% girls) via coded observations of parent–child interactions in the laboratory and in study 3 (N=1370; 53% girls) via self report. Results from all the three studies showed that youth homozygous for the functional short allele of 5-HTTLPR were more responsive to parenting as environmental context in a ‘for better and worse' manner. Specifically, the genetically susceptible youth (that is, S'S' group) who experienced unsupportive, non-positive parenting exhibited low levels of positive affect, whereas higher levels of positive affect were reported by genetically susceptible youth under supportive and positive parenting conditions. These GxE findings are consistent with the DSH and may inform etiological models and interventions in developmental psychopathology focused on positive emotion, parenting and genetic susceptibility.
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影响因子：
11
作者：
通讯作者：
--
影响因子：
4
作者：
Belsky, J;Booth-LaForce, CL;Weinraub, M
通讯作者：
Weinraub, M
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van Ijzendoorn, Marinus H.
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Anchordoquy, HC;McGeary, C;Smolen, A
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