Dermoskeleton morphogenesis in zebrafish fins.

Dermoskeleton morphogenesis in zebrafish fins.
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DOI:
10.1002/dvdy.22444
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发表时间:
2010-11
影响因子:
2.5
通讯作者:
Murciano, Carmen
Murciano, Carmen
中科院分区:
生物学3区
文献类型:
--
作者:
Mari-Beffa, Manuel;Murciano, Carmen

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斑马鱼鳍的近端骨骼由软骨内骨组成,远端骨骼由真皮骨骼组成。最近的实验和遗传学研究正在发现控制鳍骨骼形态发生的机制。虽然软骨内骨骼已经被广泛研究,但真皮骨骼的形成还需要进一步修订。鳍的真皮骨架的形状是在其远端生长边缘和沿近端生长区域产生的。在这些位置,皮肤骨骼鳍的形态发生可以通过组织间的相互作用和几种遗传途径的作用来解释。这些通路沿三个轴调节图案、大小和细胞分化。最后,目前正在分析鳍皮肤骨骼后期发育、再生和组织动态平衡的共同遗传控制。这些途径可能是导致每次形态发生过程后获得相似形状的原因。这为今后对这一主题的研究提供了一个有趣的概念框架。《发展动力学》239:2779-2794,2010。©2010 Wiley-Liss公司。
Zebrafish fins have a proximal skeleton of endochondral bones and a distal skeleton of dermal bones. Recent experimental and genetic studies are discovering mechanisms to control fin skeleton morphogenesis. Whereas the endochondral skeleton has been extensively studied, the formation of the dermal skeleton requires further revision. The shape of the dermal skeleton of the fin is generated in its distal growing margin and along a proximal growing domain. In these positions, dermoskeletal fin morphogenesis can be explained by intertissue interactions and the function of several genetic pathways. These pathways regulate patterning, size, and cell differentiation along three axes. Finally, a common genetic control of late development, regeneration, and tissue homeostasis of the fin dermoskeleton is currently being analyzed. These pathways may be responsible for the similar shape obtained after each morphogenetic process. This provides an interesting conceptual framework for future studies on this topic. Developmental Dynamics 239:2779–2794, 2010. © 2010 Wiley-Liss, Inc.
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