Disappearing polymorphs revisited.

Disappearing polymorphs revisited.
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DOI:
10.1002/anie.201410356
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发表时间:
2015-06-08
影响因子:
16.6
通讯作者:
Bernstein, Joel
Bernstein, Joel
中科院分区:
化学1区
文献类型:
--
作者:
Bucar, Dejan-Kresimir;Lancaster, Robert W.;Bernstein, Joel

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大约二十年前,杜尼茨和伯恩斯坦描述了一系列有趣的多晶型物消失案例。对于固态科学家来说,无法获得先前制备的晶型确实是一个令人沮丧且可能严重的问题。本综述讨论了最近发生的多晶型物消失的情况和例子(以及难以捉摸的晶体形式的出现),以证明固态研究中这种麻烦但总是令人着迷的现象的持久相关性。其中许多实例已成为专利诉讼中的核心问题。因此,这篇评论也强调了晶体化学与定律之间的复杂关系。
Nearly twenty years ago, Dunitz and Bernstein described a selection of intriguing cases of polymorphs that disappear. The inability to obtain a crystal form that has previously been prepared is indeed a frustrating and potentially serious problem for solid-state scientists. This Review discusses recent occurrences and examples of disappearing polymorphs (as well as the emergence of elusive crystal forms) to demonstrate the enduring relevance of this troublesome, but always captivating, phenomenon in solid-state research. A number of these instances have been central issues in patent litigations. This Review, therefore, also highlights the complex relationship between crystal chemistry and the law.
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