Emerging role of chemoprotective agents in the dynamic shaping of plasma membrane organization.
Emerging role of chemoprotective agents in the dynamic shaping of plasma membrane organization.
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DOI：
10.1016/j.bbamem.2017.03.014
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Chapkin RS
中科院分区：
文献类型：
--
作者：
Fuentes NR;Salinas ML;Kim E;Chapkin RS
在有机体的背景下，上皮细胞本质上被设计为自我与外界之间的决定性屏障。对于形成消化道内壁的上皮细胞来说尤其如此，它们吸收营养并充当有害物质的屏障。这些细胞不断地沐浴在内源性（胆汁酸、粘液、微生物代谢物）和外源性（食物、营养素、药物）生物活性化合物的复杂混合物中。从细胞生物学的角度来看，这种类型的暴露会直接影响质膜，质膜由无数复杂的脂质和蛋白质组成。质膜不仅充当屏障，而且充当细胞信号复合物形成和发挥作用的介质。这种特性是由质膜的组织介导的，质膜的组织在时间上（纳秒到分钟）和空间上（纳米到微米）受到精确的调节。由于肠腔中发现的许多生物活性化合物可以直接与脂质膜相互作用，因此我们假设质膜组织的动态重塑是选择膜靶向膳食生物活性物质（MTDB）的化学保护作用的基础。
In the context of an organism, epithelial cells by nature are designed to be the defining barrier between self and the outside world. This is especially true for the epithelial cells that form the lining of the digestive tract, which absorb nutrients and serve as a barrier against harmful substances. These cells are constantly bathed by a complex mixture of endogenous (bile acids, mucus, microbial metabolites) and exogenous (food, nutrients, drugs) bioactive compounds. From a cell biology perspective, this type of exposure would directly impact the plasma membrane, which consists of a myriad of complex lipids and proteins. The plasma membrane not only functions as a barrier but also as the medium in which cellular signaling complexes form and function. This property is mediated by the organization of the plasma membrane, which is exquisitely temporally (nanoseconds to minutes) and spatially (nanometers to micrometers) regulated. Since numerous bioactive compounds found in the intestinal lumen can directly interact with lipid membranes, we hypothesize that the dynamic reshaping of plasma membrane organization underlies the chemoprotective effect of select membrane targeted dietary bioactives (MTDBs).
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影响因子：
29.4
作者：
BARTRAM, HP;GOSTNER, A;KASPER, H
通讯作者：
KASPER, H
DOI：
10.1083/jcb.201307055
发表时间：
2014-03-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ariotti N;Fernández-Rojo MA;Zhou Y;Hill MM;Rodkey TL;Inder KL;Tanner LB;Wenk MR;Hancock JF;Parton RG
通讯作者：
Parton RG
影响因子：
4.2
作者：
Chang, WCL;Chapkin, RS;Lupton, JR
通讯作者：
Lupton, JR
影响因子：
11.2
作者：
Adachi, Seiji;Nagao, Tomokazu;Weinstein, I. Bernard
通讯作者：
Weinstein, I. Bernard
影响因子：
29.4
作者：
ANTI, M;ARMELAO, F;GASBARRINI, G
通讯作者：
GASBARRINI, G