Potential applications and human biosafety of nanomaterials used in nanomedicine.

Potential applications and human biosafety of nanomaterials used in nanomedicine.
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纳米医学中使用的纳米材料的潜在应用和人类生物安全。

DOI:
10.1002/jat.3476
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发表时间:
2018-01
期刊:
Journal of applied toxicology : JAT
影响因子:
--
通讯作者:
Ding M
Ding M
中科院分区:
其他
文献类型:
--
作者:
Su H;Wang Y;Gu Y;Bowman L;Zhao J;Ding M

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近年来,随着纳米技术的迅速发展,纳米材料在医学上的潜在应用得到了广泛的研究。纳米材料本身可以用作显像剂或治疗药物,也可以用于药物和基因传递、生物装置、纳米电子生物传感器或分子纳米技术。随着纳米材料的组成、形态、化学性质、植入部位以及潜在应用领域的日益复杂,临床应用纳米材料的人体生物安全性已成为人们关注的焦点。如果纳米颗粒在人体内积累或与人体分子或化学成分相互作用,也可能产生健康风险。因此,本文对其独特的化学和物理性质、在医学领域的潜在应用以及临床试验中的人体生物安全性进行了综述。最后,对今后纳米医学的研究工作提出了建议。
With the rapid development of nanotechnology, potential applications of nanomaterials in medicine have been widely researched in recent years. Nanomaterials themselves can be used as image agents or therapeutic drugs, and for drug and gene delivery, biological devices, nanoelectronic biosensors or molecular nanotechnology. As the composition, morphology, chemical properties, implant sites as well as potential applications become more and more complex, human biosafety of nanomaterials for clinical use has become a major concern. If nanoparticles accumulate in the human body or interact with the body molecules or chemical components, health risks may also occur. Accordingly, the unique chemical and physical properties, potential applications in medical fields, as well as human biosafety in clinical trials are reviewed in this study. Finally, this article tries to give some suggestions for future work in nanomedicine research.
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