Large-scale spontaneous fluctuations and correlations in brain electrical activity observed with magnetoencephalography.
Large-scale spontaneous fluctuations and correlations in brain electrical activity observed with magnetoencephalography.
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DOI：
10.1016/j.neuroimage.2010.01.092
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发表时间：
2010-05-15
期刊：
影响因子：
5.7
通讯作者：
Duyn, Jeff H.
中科院分区：
文献类型：
--
作者：
Liu, Zhongming;Fukunaga, Masaki;de Zwart, Jacco A.;Duyn, Jeff H.
关键词：
静息功能磁共振成像(FMRI)的广泛应用，极大地扩展了人们对人脑内在功能结构的认识。然而，自发的fMRI信号改变的神经生理学相关性和起源仍然知之甚少。在本研究中，我们研究了受试者在清醒休息(睁眼闭眼)和轻度睡眠时的自发脑磁图(MEG)节律的功率调制。通过频谱、相关和相干分析，我们发现静息状态的脑磁图节律表现出超低(<；0.1赫兹)的自发功率调制，并且在很大的空间距离上同步，特别是在相反半球的两侧同源区域之间。这些观察结果与已知的自发fMRI信号的时空特性相一致，并进一步表明自发节律活动的相干功率调制反映了先前在静息脑中用fMRI观察到的大规模功能网络的电生理特征。
Knowledge about the intrinsic functional architecture of the human brain has been greatly expanded by the extensive use of resting-state functional magnetic resonance imaging (fMRI). However, the neurophysiological correlates and origins of spontaneous fMRI signal changes remain poorly understood. In the present study, we characterized the power modulations of spontaneous magnetoencephalography (MEG) rhythms recorded from human subjects during wakeful rest (with eyes open and eyes closed) and light sleep. Through spectral, correlation and coherence analyses, we found that resting-state MEG rhythms demonstrated ultraslow (<0.1 Hz) spontaneous power modulations that synchronized over a large spatial distance, especially between bilaterally homologous regions in opposite hemispheres. These observations are in line with the known spatio-temporal properties of spontaneous fMRI signals, and further suggest that the coherent power modulation of spontaneous rhythmic activity reflects the electrophysiological signature of the large-scale functional networks previously observed with fMRI in the resting brain.
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影响因子：
4.7
作者：
Bastiaansen, MCM;Knösche, TR
通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.0807010105
发表时间：
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作者：
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