IL-1 in gingival crevicular fluid following closed root planing and papillary flap debridement.
IL-1 in gingival crevicular fluid following closed root planing and papillary flap debridement.
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闭合根面平整和乳头瓣清创后龈沟液中的 IL-1。
DOI：
10.1111/j.1600-051x.1993.tb00400.x
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发表时间：
1993
影响因子：
6.7
通讯作者：
Anthony C. Allison
中科院分区：
文献类型：
--
作者：
Richard A. Reinhardt;M. P. Masada;Georgia K. Johnson;Linda M. DuBois;Gregory J. Seymour;Anthony C. Allison
白细胞介素(IL)-1 α和β是在牙周组织中介导炎症、骨吸收和修复作用的细胞因子，但很少有纵向数据研究它们在牙周治疗后的作用。本研究检测了同一受试者（n = 14例）在封闭刮治/根治（SC/RP）或乳头瓣清创（PFD）治疗前和治疗后6个月龈沟液（GCF）中浅沟（SS）或炎症中/晚期袋（M/AP）部位IL-1 α和IL-1 β的浓度。在基线时，SS和M/AP位点之间IL-1 α或β浓度（用双位点酶联免疫吸附测定）没有显著差异。两种治疗方法均能改善牙周病的临床参数，治疗6个月后M/AP-PFD部位IL-1 α浓度显著升高（p < 0.05），而其他组无明显变化。除M/AP-PFD部位IL-1 β浓度显著升高（p < 0.05）外，治疗后数值上IL-1 β浓度降低。这些数据表明，在炎症斑块感染部位（M/AP-PFD）的手术伤口愈合导致IL-1的产生延长，这可能反映了组织创伤的程度和伤口愈合的延迟。尽管IL-1水平升高，但这些部位术后临床附着水平短期内有显著改善（+ 1.8 mm, p <或= 0.001）。
Interleukin (IL)-1 alpha and beta are cytokines which can mediate inflammatory, bone resorbing, and reparative effects in the periodontium, but few longitudinal data exist exploring their role following periodontal therapy. This study examined gingival crevicular fluid (GCF) concentrations of IL-1 alpha and IL-1 beta at sites with shallow sulci (SS) or inflamed moderate/advanced pockets (M/AP) before and 6 months after treatment with closed scaling/root planing (SC/RP) or papillary flap debridement (PFD), all in the same subject (n = 14 patients). No significant differences were noted in IL-1 alpha or beta concentrations (determined with two-site enzyme-linked immunosorbent assays) between SS and M/AP sites at baseline. While both therapies improved clinical parameters of periodontal disease, IL-1 alpha concentration increased significantly (p < 0.05) in M/AP-PFD sites 6 months after treatment, but were unchanged in other groups. IL-1 beta concentrations were numerically lower after therapy, except for a significant increase (p < 0.05) in M/AP-PFD sites. These data suggest that surgical wound healing in an inflamed, plaque-infected site (M/AP-PFD) results in prolonged production of IL-1, which may be a reflection of the extent of tissue trauma and delayed wound healing. In spite of increased IL-1 levels, these sites demonstrated significant short-term improvement in clinical attachment level (+ 1.8 mm, p < or = 0.001) postoperatively.
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影响因子：
6.7
作者：
Philip Stashenko;P. Fujiyoshi;M. Obernesser;L. Prostak;A. Haffajee;S. Socransky
通讯作者：
Philip Stashenko;P. Fujiyoshi;M. Obernesser;L. Prostak;A. Haffajee;S. Socransky
影响因子：
4.3
作者：
STASHENKO, P;JANDINSKI, JJ;SOCRANSKY, SS
通讯作者：
SOCRANSKY, SS
免疫细胞因子对骨的影响。
影响因子：
2.8
作者：
Stashenko,P;Obernesser,MS;Dewhirst,FE
通讯作者：
Dewhirst,FE
膜白细胞介素 1 对人内皮细胞和真皮成纤维细胞的诱导。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kurt-Jones,EA;Fiers,W;Pober,JS
通讯作者：
Pober,JS
影响因子：
3.3
作者：
Page,RC
通讯作者：
Page,RC