Individual differences in T1w/T2w ratio development during childhood.
Individual differences in T1w/T2w ratio development during childhood.
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DOI：
10.1016/j.dcn.2023.101270
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发表时间：
2023-08
影响因子：
4.7
通讯作者：
Mackey, Allyson P.
中科院分区：
文献类型：
--
作者：
Boroshok, Austin L.;McDermott, Cassidy L.;Fotiadis, Panagiotis;Park, Anne T.;Tooley, Ursula A.;Gatavins, Martins M.;Tisdall, M. Dylan;Bassett, Dani S.;Mackey, Allyson P.
髓鞘形成是促进快速和有效的信息传递的关键发育过程。髓鞘还稳定现有的大脑网络，因此可能会限制神经可塑性，这里定义为大脑响应经验而改变的潜力，而不是规范定义为改变的过程。表征神经可塑性的个体差异可能揭示早期经验塑造学习，大脑和身体发育以及对干预措施的反应的机制。T1加权/T2加权（T1 w/T2 w）MRI信号比是皮质微结构和神经可塑性的替代指标。在这里，在预先登记的分析中，我们研究了儿童（4-10岁，n = 157）T1 w/T2 w比值的个体差异。T1 w/T2 w比值与早期发育的感觉运动和注意力区域的年龄呈正相关。我们还测试了社会经济地位，认知（结晶知识或流体推理）和生物年龄（以磨牙萌出测量）是否与T1 w/T2 w信号相关，但没有发现显着影响。T1 w/T2 w比值、早期经历和认知之间的关联可能在青春期后期出现，并且可能不足以在中等样本量中检测到。
Myelination is a key developmental process that promotes rapid and efficient information transfer. Myelin also stabilizes existing brain networks and thus may constrain neuroplasticity, defined here as the brain's potential to change in response to experiences rather than the canonical definition as the process of change. Characterizing individual differences in neuroplasticity may shed light on mechanisms by which early experiences shape learning, brain and body development, and response to interventions. The T1-weighted/T2-weighted (T1w/T2w) MRI signal ratio is a proxy measure of cortical microstructure and thus neuroplasticity. Here, in pre-registered analyses, we investigated individual differences in T1w/T2w ratios in children (ages 4–10, n = 157). T1w/T2w ratios were positively associated with age within early-developing sensorimotor and attention regions. We also tested whether socioeconomic status, cognition (crystallized knowledge or fluid reasoning), and biological age (as measured with molar eruption) were related to T1w/T2w signal but found no significant effects. Associations among T1w/T2w ratios, early experiences, and cognition may emerge later in adolescence and may not be strong enough to detect in moderate sample sizes.
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DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
影响因子：
4.6
作者：
Hagiwara A;Hori M;Kamagata K;Warntjes M;Matsuyoshi D;Nakazawa M;Ueda R;Andica C;Koshino S;Maekawa T;Irie R;Takamura T;Kumamaru KK;Abe O;Aoki S
通讯作者：
Aoki S
DOI：
10.1093/cercor/bhac515
发表时间：
2023-05-09
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Hanson, Jamie L.;Hair, Nicole;Pollak, Seth D.
通讯作者：
Pollak, Seth D.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y