Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods.
Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods.
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DOI：
10.1038/s41598-018-28852-6
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发表时间：
2018-07-12
影响因子：
4.6
通讯作者：
Aoki S
中科院分区：
文献类型：
--
作者：
Hagiwara A;Hori M;Kamagata K;Warntjes M;Matsuyoshi D;Nakazawa M;Ueda R;Andica C;Koshino S;Maekawa T;Irie R;Takamura T;Kumamaru KK;Abe O;Aoki S
磁化传递（MT）成像已被广泛用于估计髓鞘含量在大脑中。最近，另外两种方法，即R1和R2弛豫率和质子密度的同时组织弛豫测量法（SyMRI）和T1加权与T2加权图像的比率（T1w/T2w比率），也被提出作为测量髓鞘的方法。据报道，SyMRI和MT成像与组织学的实际髓鞘有很好的相关性。然而，对于T1w/T2w比值，此类证据有限。在20名健康成年人中，我们使用MT饱和指数（MTsat）进行MT成像，研究了这三种方法之间的相关性。校准后，在这三个指标中，SyMRI的白色物质（WM）与灰质（GM）对比度最高。尽管SyMRI和MTsat在WM中显示出强相关性（r = 0.72），但在T1w/T2w与SyMRI（r = 0.45）或MTsat（r = 0.38）之间仅发现弱相关性（相关系数彼此显著不同，p值<0.001）。在皮质下和皮质GM，这些测量结果显示出中度至强相关性（r = 0.54至0.78）。总之，SyMRI和MTsat之间的高度相关性表明，这两种方法同样适用于测量WM中的髓鞘，而T1w/T2w比值可能不太理想。
Magnetization transfer (MT) imaging has been widely used for estimating myelin content in the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R1 and R2 relaxation rates and proton density (SyMRI) and the ratio of T1-weighted to T2-weighted images (T1w/T2w ratio), were also proposed as methods for measuring myelin. SyMRI and MT imaging have been reported to correlate well with actual myelin by histology. However, for T1w/T2w ratio, such evidence is limited. In 20 healthy adults, we examined the correlation between these three methods, using MT saturation index (MTsat) for MT imaging. After calibration, white matter (WM) to gray matter (GM) contrast was the highest for SyMRI among these three metrics. Even though SyMRI and MTsat showed strong correlation in the WM (r = 0.72), only weak correlation was found between T1w/T2w and SyMRI (r = 0.45) or MTsat (r = 0.38) (correlation coefficients significantly different from each other, with p values < 0.001). In subcortical and cortical GM, these measurements showed moderate to strong correlations to each other (r = 0.54 to 0.78). In conclusion, the high correlation between SyMRI and MTsat indicates that both methods are similarly suited to measure myelin in the WM, whereas T1w/T2w ratio may be less optimal.
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DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
影响因子：
9.9
作者：
FILIPPI, M;CAMPI, A;COMI, G
通讯作者：
COMI, G
影响因子：
4.2
作者：
Cercignani M;Giulietti G;Dowell NG;Gabel M;Broad R;Leigh PN;Harrison NA;Bozzali M
通讯作者：
Bozzali M
影响因子：
3.3
作者：
Dula, Adrienne N.;Gochberg, Daniel F.;Valentine, Holly L.;Valentine, William M.;Does, Mark D.
通讯作者：
Does, Mark D.
影响因子：
3.5
作者：
Hagiwara, A.;Hori, M.;Aoki, S.
通讯作者：
Aoki, S.