Peptide TQS169 prevents osteoporosis in rats by enhancing osteogenic differentiation and calcium absorption
Peptide TQS169 prevents osteoporosis in rats by enhancing osteogenic differentiation and calcium absorption
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肽TQS169通过增强成骨分化和钙吸收预防大鼠骨质疏松
DOI：
10.1016/j.jff.2018.08.021
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发表时间：
2018-10
影响因子：
5.6
通讯作者：
Wei Zhou
中科院分区：
文献类型：
--
作者：
Wei Zhou
本研究探讨了TQS169肽对骨质疏松症的预防作用，并在体外和体内研究了促进成骨分化和钙吸收的机制。 Wistar大鼠接受低钙饮食，并用不同剂量的肽TQS169和额外的CaCl2治疗4周。高剂量组大鼠血清钙、OPG含量及股骨Ca含量升高。建立维A酸诱导的骨质疏松模型并测定相关因素。高剂量TQS169治疗组显示出保护作用。 TQS169处理后的MC3T3-E1细胞通过提高ALP活性、促进矿物质基质形成以及RUNX2、OCN和COL I典型基因的表达而加速成骨细胞分化。综合所有实验，我们的研究证实了TQS169对骨质疏松的保护作用，并首次解释了其潜在机制。
The preventive effects of TQS169 peptide on osteoporosis were investigated and the mechanisms of promoting osteogenic differentiation and calcium absorption were also studiedin vitroandvivoin this research. Wistar rats were given a low-Calcium diet treated with different doses of peptide TQS169 and extra CaCl2for 4 weeks. The content of Calcium, OPG in serum and the Ca content of the femur were increased in high-dose-treated rats. The osteoporosis model induced by retinoic acid was established to measure the related factors. High dosage of TQS169 treated group showed the protective effects. Osteoblastogenesis differentiation of MC3T3-E1 cells treated with TQS169 were accelerated through improving ALP activity, promoting mineral matrix formation and the expression of typical genes of RUNX2, OCN and COL I. Taking all the experiments together, our study confirms the protective effects of TQS169 on osteoporosis and explains the potential mechanism for the first time.
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