The Association of Maternal Age With Fetal Growth and Newborn Measures: The Mumbai Maternal Nutrition Project (MMNP).
The Association of Maternal Age With Fetal Growth and Newborn Measures: The Mumbai Maternal Nutrition Project (MMNP).
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DOI：
10.1177/1933719118799202
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发表时间：
2019-07
期刊：
影响因子：
--
通讯作者：
Fall CHD
中科院分区：
文献类型：
--
作者：
Di Gravio C;Lawande A;Potdar RD;Sahariah SA;Gandhi M;Brown N;Chopra H;Sane H;Kehoe SH;Marley-Zagar E;Margetts BM;Jackson AA;Fall CHD
低龄产妇与较差的出生结果相关，但其机制尚不完全清楚。利用居住在印度孟买贫民窟的孕妇前瞻性队列的数据，我们测试了较低的产妇年龄是否与胎儿生长不良有关。胎儿冠臀长 (CRL) 在妊娠 10 周（9-10 周）的中位数（四分位距，IQR）处记录。在第 19 (19-20) 周和第 29 (28-30) 周时记录头围 (HC)、双顶径 (BPD)、股骨长度 (FL) 和腹围 (AC)。新生儿在分娩后 2 天（1-3 天）的中位值 (IQR) 进行测量。使用前瞻性收集的月经日期来评估妊娠。样本包括 1653 个没有重大先天异常的单胎胎儿，其中 1360 个进行了新生儿测量。年轻母亲的胎儿在随后的就诊中具有较小的 CRL（每岁母亲年龄 0.01 标准差 [SD]；95% 置信区间 CI：0.00-0.02；P = 0.04），并且 HC、FL 和 AC 较小。 HC (0.04 cm; 95% CI: 0.02-0.05; P < .001)、BPD (0.01 cm; 95% CI: 0.00-0.01; P = .009)、FL (0.04 cm; 95% CI: 0.02-0.06; P < .001) 和 AC (0.01) 的胎儿生长情况厘米；95%置信区间： 0.00-0.01； P = .003) 直到妊娠晚期随着母亲年龄的增加而增加。年轻母亲的新生儿的皮褶、头围和中上臂围较小。根据母亲孕前的社会经济状况、体重指数、身高和胎次进行调整，减弱了母亲年龄和新生儿体型之间的关联，但没有改变与胎儿生物特征的关联。年轻母亲的胎儿从妊娠前三个月开始就较小，生长速度也较慢，与已知的混杂因素无关。
Young maternal age is associated with poorer birth outcomes, but the mechanisms are incompletely understood. Using data from a prospective cohort of pregnant women living in Mumbai slums, India, we tested whether lower maternal age was associated with adverse fetal growth. Fetal crown-rump length (CRL) was recorded at a median (interquartile range, IQR) of 10 weeks’ gestation (9-10 weeks). Head circumference (HC), biparietal diameter (BPD), femur length (FL), and abdominal circumference (AC) were recorded at 19 (19-20) and 29 (28-30) weeks. Newborns were measured at a median (IQR) of 2 days (1-3 days) from delivery. Gestation was assessed using prospectively collected menstrual period dates. The sample comprised 1653 singleton fetuses without major congenital abnormalities, of whom 1360 had newborn measurements. Fetuses of younger mothers had smaller CRL (0.01 standard deviation [SD] per year of maternal age; 95% confidence interval CI: 0.00-0.02; P = .04), and smaller HC, FL, and AC at subsequent visits. Fetal growth of HC (0.04 cm; 95% CI: 0.02-0.05; P < .001), BPD (0.01 cm; 95% CI: 0.00-0.01; P = .009), FL (0.04 cm; 95% CI: 0.02-0.06; P < .001), and AC (0.01 cm; 95% CI: 0.00-0.01; P = .003) up to the third trimester increased with maternal age. Skinfolds, head, and mid-upper arm circumferences were smaller in newborns of younger mothers. Adjusting for maternal prepregnancy socioeconomic status, body mass index, height, and parity attenuated the associations between maternal age and newborn size but did not change those with fetal biometry. Fetuses of younger mothers were smaller from the first trimester onward and grew slower, independently of known confounding factors.
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影响因子：
120.7
作者：
Mook-Kanamori, Dennis O.;Steegers, Eric A. P.;Jaddoe, Vincent W. V.
通讯作者：
Jaddoe, Vincent W. V.
影响因子：
2
作者：
COLE, TJ;GREEN, PJ
通讯作者：
GREEN, PJ
影响因子：
3.6
作者：
Rumball, Christopher W. H.;Bloomfield, Frank H.;Harding, Jane E.
通讯作者：
Harding, Jane E.
DOI：
10.1016/s2214-109x(15)00038-8
发表时间：
2015-07
期刊：
The Lancet. Global health
影响因子：
--
作者：
Fall CH;Sachdev HS;Osmond C;Restrepo-Mendez MC;Victora C;Martorell R;Stein AD;Sinha S;Tandon N;Adair L;Bas I;Norris S;Richter LM;COHORTS investigators
通讯作者：
COHORTS investigators
影响因子：
3.1
作者：
Lamminpää R;Vehviläinen-Julkunen K;Gissler M;Heinonen S
通讯作者：
Heinonen S