Vitamin D status and circulating biomarkers of endothelial dysfunction and inflammation in non-diabetic obese individuals: a pilot study.
Vitamin D status and circulating biomarkers of endothelial dysfunction and inflammation in non-diabetic obese individuals: a pilot study.
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DOI：
10.5114/aoms.2016.61812
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发表时间：
2017-02-01
期刊：
影响因子：
--
通讯作者：
Isenovic ER
中科院分区：
文献类型：
--
作者：
Ilinčić B;Stokić E;Stošić Z;Kojić NE;Katsiki N;Mikhailidis DP;Isenovic ER
肥胖和维生素D不足与内皮功能障碍和心血管疾病有关。我们评估了维生素D状态（即25-羟基维生素D（25（OH）D）的血清水平）、内皮功能障碍的生物标志物（即可溶性细胞间粘附分子1（sICAM-1）和可溶性E-选择素（sE-选择素）的血清浓度）、炎症标志物（即高敏C反应蛋白（hsCRP）和纤维蛋白原）和心脏代谢危险因素之间的相关性。纳入了50例肥胖（体重指数（BMI）≥ 30 kg/m2）、无既存心血管异常的非糖尿病成人（平均年龄：36.2 ±5.4岁）和25例临床健康、体重正常且年龄匹配的个体。评估所有受试者的人体测量参数、葡萄糖和脂质代谢标志物以及炎症和内皮功能障碍标志物的血清水平。肥胖组的平均血清25（OH）D水平显著低于对照组（33.5 ±15.2 vs. 60.1 ±23.1 nmol/l; p < 0.001）。在肥胖组中，（36.4（32.1-47.2）对比32.4（24.6-35.5）ng/ml，p < 0.05）和hsCRP（6.0 ±3.4 vs. 3.5 ±1.0 mg/l，p < 0.05）在维生素D水平低于中位数的个体中显著较高（即31 nmol/l）与维生素D水平较高的人相比。在多变量线性回归分析中，hsCRP（β = -0.43; p < 0.001）和sE-选择素（β = -0.30; p = 0.03）与肥胖组血清25（OH）D水平独立且显著相关。维生素D水平可能与肥胖非糖尿病个体中内皮功能障碍和炎症的生物标志物水平增加有关。
Obesity and inadequate vitamin D status are associated with endothelial dysfunction and cardiovascular disease. We evaluated the associations between vitamin D status (i.e. serum levels of 25-hydroxyvitamin D (25(OH)D)), biomarkers of endothelial dysfunction (i.e. serum concentrations of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble E-selectin (sE-selectin)), inflammatory markers (i.e. high-sensitivity C-reactive protein (hsCRP) and fibrinogen) and cardiometabolic risk factors. Fifty obese (body mass index (BMI) ≥ 30 kg/m2) non-diabetic adults (mean age: 36.2 ±5.4 years) without pre-existing cardiovascular abnormalities and 25 clinically healthy, normal weight and age-matched individuals were included. Anthropometric parameters, markers of glucose and lipid metabolism, and serum levels of inflammatory and endothelial dysfunction biomarkers were assessed in all subjects. The mean serum 25(OH)D level was significantly lower in the obese group than in controls (33.5 ±15.2 vs. 60.1 ±23.1 nmol/l; p < 0.001). In the obese group, sE-selectin (36.4 (32.1–47.2) vs. 32.4 (24.6–35.5) ng/ml, p < 0.05) and hsCRP (6.0 ±3.4 vs. 3.5 ±1.0 mg/l, p < 0.05) were significantly higher in individuals with lower than median vitamin D levels (i.e. 31 nmol/l) compared with those with higher vitamin D levels. In multivariable linear regression analysis, hsCRP (β = –0.43; p < 0.001) and sE-selectin (β = –0.30; p = 0.03) were independently and significantly associated with serum 25(OH)D levels in the obese group. Vitamin D levels may be related to increased levels of biomarkers of endothelial dysfunction and inflammation in obese non-diabetic individuals.
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