Prediagnostic smoking history, alcohol consumption, and colorectal cancer survival: the Seattle Colon Cancer Family Registry.
Prediagnostic smoking history, alcohol consumption, and colorectal cancer survival: the Seattle Colon Cancer Family Registry.
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DOI：
10.1002/cncr.26114
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发表时间：
2011-11-01
期刊：
影响因子：
6.2
通讯作者：
Newcomb PA
中科院分区：
文献类型：
--
作者：
Phipps AI;Baron J;Newcomb PA
吸烟和饮酒与患结直肠癌的风险增加有关。然而，目前尚不清楚这些暴露是否与结直肠癌诊断后的存活率有关。华盛顿州西部13个县1998-2007年间被诊断为偶发结直肠癌的男性和女性被使用监测、流行病学和最终结果癌症登记确定。通过电话访问收集有关吸烟史和饮酒的信息。通过与国家死亡指数建立联系，完成了对死亡率的跟踪。用COX比例风险回归估计吸烟、饮酒和结直肠癌确诊后死亡率之间的风险比(HR)和95%可信区间(CI)；分层分析按性别、确诊时年龄(<；50，≥50)、肿瘤部位(近端、远端、直肠)、分期(I-II、III-IV)和微卫星不稳定状态(稳定/低、高)进行。吸烟者的疾病特定死亡率和全因死亡率显著高于不吸烟者(HR=1.30，95%CI：1.09~1.74；HR=1.51，95%CI：1.24~1.83)。然而，这种关联在具有高度微卫星不稳定性的肿瘤中最为显著(HR=3.83，95%CI：1.32-11.11)，而不包括直肠癌患者(HR=1.08，95%CI：0.72-1.61)或50岁前确诊的患者(HR=0.99，95%CI：0.67-1.48)。无论患者或肿瘤的特征如何，饮酒与疾病特异性或全因死亡率无关。除了与疾病风险有关外，吸烟还与结直肠癌确诊后死亡率的增加有关。这种关联在微卫星高度不稳定的结直肠癌中尤其明显。
Smoking and alcohol consumption are associated with an increased risk of developing colorectal cancer. However, it is unclear whether these exposures are associated with survival after colorectal cancer diagnosis. Men and women diagnosed with incident colorectal cancer between 1998-2007 in 13 counties in western Washington State were identified using the Surveillance, Epidemiology, and End Results cancer registry. Information on smoking history and alcohol consumption was collected by telephone interview. Follow-up for mortality was completed through linkage to the National Death Index. Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between smoking, alcohol consumption, and mortality after colorectal cancer diagnosis; stratified analyses were conducted by sex, age at diagnosis (<50, ≥50), tumor site (proximal, distal, rectal), stage (I-II, III-IV), and microsatellite instability status (stable/low, high). Disease-specific and all-cause mortality were significantly higher for smokers compared to never-smokers (HR=1.30, 95% CI: 1.09-1.74; HR=1.51, 95% CI: 1.24-1.83, respectively). However, this association was most prominent in those with tumors exhibiting high microsatellite instability (HR=3.83, 95% CI: 1.32-11.11) and did not extend to those with rectal cancer (HR=1.08, 95% CI: 0.72-1.61) or those diagnosed before age 50 (HR=0.99, 95% CI: 0.67-1.48). Alcohol consumption was not associated with disease-specific or all-cause mortality, regardless of patient or tumor characteristics. In addition to an association with disease risk, smoking is associated with increased mortality after colorectal cancer diagnosis. This association is especially pronounced for colorectal cancer with high microsatellite instability.
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影响因子：
24.5
作者：
Coghill AE;Newcomb PA;Campbell PT;Burnett-Hartman AN;Adams SV;Poole EM;Potter JD;Ulrich CM
通讯作者：
Ulrich CM
影响因子：
39.2
作者：
Gronbæk, M;Becker, U;Sorensen, TIA
通讯作者：
Sorensen, TIA
影响因子：
11.5
作者：
Russo, AL;Thiagalingam, A;Thiagalingam, S
通讯作者：
Thiagalingam, S
影响因子：
6.4
作者：
Moskal, Aurelie;Norat, Teresa;Riboli, Elio
通讯作者：
Riboli, Elio
影响因子：
3.4
作者：
Munro, A. J.;Bentley, A. H. M.;Boyle, P. J.
通讯作者：
Boyle, P. J.