Establishing, maintaining and modifying DNA methylation patterns in plants and animals.

Establishing, maintaining and modifying DNA methylation patterns in plants and animals.
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DOI:
10.1038/nrg2719
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发表时间:
2010-03
期刊:
Nature reviews. Genetics
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其他
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Cytosine DNA methylation is a stable epigenetic mark that is critical for diverse biological processes including gene and transposon silencing, imprinting, and X chromosome inactivation. Recent findings in plants and animals have greatly increased our understanding of the pathways utilized to accurately target, maintain, and modify patterns of DNA methylation and have revealed unanticipated mechanistic similarities between these organisms. Key roles for small RNAs, proteins with methylated DNA binding domains and DNA glycosylases in these processes have emerged. Drawing on insights from both plants and animals should deepen our understanding of the regulation and biological significance of DNA methylation.
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