Cognitive Fatigue Is Associated with Altered Functional Connectivity in Interoceptive and Reward Pathways in Multiple Sclerosis.
Cognitive Fatigue Is Associated with Altered Functional Connectivity in Interoceptive and Reward Pathways in Multiple Sclerosis.
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DOI：
10.3390/diagnostics10110930
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发表时间：
2020-11-10
期刊：
影响因子：
--
通讯作者：
Wylie GR
中科院分区：
文献类型：
--
作者：
Chen MH;DeLuca J;Genova HM;Yao B;Wylie GR
认知疲劳在多发性硬化症（MS）患者中很常见并使人衰弱。疲劳的神经机制尚未得到很好的理解，这导致缺乏适当的治疗。目前的研究检查了26名老年痴呆症患者和14名人口统计学匹配的健康对照（HC）之间的认知疲劳相关功能连接。参与者在执行工作记忆任务（n-back）时进行功能性磁共振成像（fMRI）扫描，有两种条件：一种是较高的认知负荷（2-back）以诱导疲劳，另一种是较低的认知负荷（0-back）作为对照条件。评估了与任务无关的剩余功能连接，其中种子位于先前与认知疲劳有关的大脑区域（背外侧前额叶皮质（DLPFC）、腹内侧前额叶皮质（vmPFC）、背侧前扣带回皮质（dACC）、脑岛和纹状体）。认知疲劳使用视觉疲劳量表（VAS-F）进行测量。结果表明，随着VAS-F分数的增加，与0-back条件相比，在2-back条件下，HC显示纹状体和vmPFC（在奖励处理中至关重要）之间的剩余功能连接增加。相比之下，CIMMS显示出从内感受中枢-纹状体和dACC-到纹状体的残余功能连接增加。总而言之，当经历认知疲劳时，内感受性网络中的超连通性和奖励回路中的断开连接。
Cognitive fatigue is common and debilitating among persons with multiple sclerosis (pwMS). Neural mechanisms underlying fatigue are not well understood, which results in lack of adequate treatment. The current study examined cognitive fatigue-related functional connectivity among 26 pwMS and 14 demographically matched healthy controls (HCs). Participants underwent functional magnetic resonance imaging (fMRI) scanning while performing a working memory task (n-back), with two conditions: one with higher cognitive load (2-back) to induce fatigue and one with lower cognitive load (0-back) as a control condition. Task-independent residual functional connectivity was assessed, with seeds in brain regions previously implicated in cognitive fatigue (dorsolateral prefrontal cortex (DLPFC), ventromedial prefrontal cortex (vmPFC), dorsal anterior cingulate cortex (dACC), insula, and striatum). Cognitive fatigue was measured using the Visual Analogue Scale of Fatigue (VAS-F). Results indicated that as VAS-F scores increased, HCs showed increased residual functional connectivity between the striatum and the vmPFC (crucial in reward processing) during the 2-back condition compared to the 0-back condition. In contrast, pwMS displayed increased residual functional connectivity from interoceptive hubs—the insula and the dACC—to the striatum. In conclusion, pwMS showed a hyperconnectivity within the interoceptive network and disconnection within the reward circuitry when experiencing cognitive fatigue.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
DOI：
10.1073/pnas.1110024108
发表时间：
2011-11-22
影响因子：
11.1
作者：
Hawellek, David J.;Hipp, Joerg F.;Engel, Andreas K.
通讯作者：
Engel, Andreas K.
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.
影响因子：
5.7
作者：
Fonov V;Evans AC;Botteron K;Almli CR;McKinstry RC;Collins DL;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group