Coding of reward probability and risk by single neurons in animals.

Coding of reward probability and risk by single neurons in animals.
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DOI:
10.3389/fnins.2011.00121
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发表时间:
2011
影响因子:
4.3
通讯作者:
Tobler PN
Tobler PN
中科院分区:
医学2区
文献类型:
--
作者:
Burke CJ;Tobler PN

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概率和风险是基于价值的决策和最佳觅食的重要因素。为了在不可预测的世界中生存,生物体必须能够评估未来事件的概率和风险,并利用这些信息来产生适应性行为。最近对非人类灵长类动物和大鼠的研究表明,概率和风险都是在整个大脑的单个神经元水平上以分布式方式处理的。奖励概率主要由基底神经节、中脑、顶叶和额叶皮层神经元放电率的阶段性增加和减少来编码。奖励方差通过眶额皮质和后扣带皮层以及多巴胺能中脑神经元的持续反应来体现。
Probability and risk are important factors for value-based decision making and optimal foraging. In order to survive in an unpredictable world, organisms must be able to assess the probability and risk attached to future events and use this information to generate adaptive behavior. Recent studies in non-human primates and rats have shown that both probability and risk are processed in a distributed fashion throughout the brain at the level of single neurons. Reward probability has mainly been shown to be coded by phasic increases and decreases in firing rates in neurons in the basal ganglia, midbrain, parietal, and frontal cortex. Reward variance is represented in orbitofrontal and posterior cingulate cortex and through a sustained response of dopaminergic midbrain neurons.
额叶中的神经元编码多个决策变量的值。
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