Functional regulation of GABAA receptors in nervous system pathologies.
Functional regulation of GABAA receptors in nervous system pathologies.
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DOI：
10.1016/j.conb.2011.10.007
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发表时间：
2012-06
影响因子：
5.7
通讯作者：
Maguire J
中科院分区：
文献类型：
--
作者：
Hines RM;Davies PA;Moss SJ;Maguire J
抑制性神经传递主要由γ-氨基丁酸（GABA）A型受体（GABAAR）控制。GABAAR是由19个可能的亚基组合形成的异五聚体配体门控通道。GABAAR亚基受到多种类型的调节，影响组装受体的定位、性质和功能。GABAAR介导相位（突触）和强直（突触外）抑制。虽然突触受体的调控机制已经开始被定义，很少有人知道突触外受体的调节。我们研究GABAARs对神经发育障碍、精神分裂症、抑郁症、癫痫和中风发病机制的贡献，特别关注突触外GABAARs。我们认为，突触外GABAARs是治疗这些疾病的有吸引力的目标，研究应集中在描绘的机制，调节突触外GABAARs，促进新的治疗方法。
Inhibitory neurotransmission is primarily governed by γ-aminobutyric acid (GABA) type A receptors (GABAARs). GABAARs are heteropentameric ligand-gated channels formed by the combination of 19 possible subunits. GABAAR subunits are subject to multiple types of regulation, impacting the localization, properties, and function of assembled receptors. GABAARs mediate both phasic (synaptic) and tonic (extrasynaptic) inhibition. While the regulatory mechanisms governing synaptic receptors have begun to be defined, little is known about the regulation of extrasynaptic receptors. We examine the contributions of GABAARs to the pathogenesis of neurodevelopmental disorders, schizophrenia, depression, epilepsy, and stroke, with particular focus on extrasynaptic GABAARs. We suggest that extrasynaptic GABAARs are attractive targets for the treatment of these disorders, and that research should be focused on delineating the mechanisms that regulate extrasynaptic GABAARs, promoting new therapeutic approaches.
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DOI：
10.1177/0269881111405366
发表时间：
2011-08
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Braudeau J;Delatour B;Duchon A;Pereira PL;Dauphinot L;de Chaumont F;Olivo-Marin JC;Dodd RH;Hérault Y;Potier MC
通讯作者：
Potier MC
影响因子：
3.5
作者：
Di Cristo, G.
通讯作者：
Di Cristo, G.
影响因子：
2.5
作者：
El Idrissi, A;Ding, XH;Dobkin, C
通讯作者：
Dobkin, C
影响因子：
5.3
作者：
Earnheart, John C.;Schweizer, Claude;Luscher, Bernhard
通讯作者：
Luscher, Bernhard
影响因子：
4.7
作者：
Charych, Erik I.;Liu, Feng;Moss, Stephen J.;Brandon, Nicholas J.
通讯作者：
Brandon, Nicholas J.