Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel.
Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel.
复制标题
肝纤维化的评估：腹部放射学疾病焦点小组的综述。
DOI：
10.1007/s00261-017-1211-7
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Miller FH
中科院分区：
文献类型：
--
作者：
Horowitz JM;Venkatesh SK;Ehman RL;Jhaveri K;Kamath P;Ohliger MA;Samir AE;Silva AC;Taouli B;Torbenson MS;Wells ML;Yeh B;Miller FH
肝纤维化可能是可逆的，但是早期诊断对于治疗是必要的，以阻止进展为肝硬化和并发症的发展，包括门静脉高压症和肝细胞癌。超声（US）、计算机断层扫描（CT）和磁共振成像（MRI）单独显示肝硬化的形态学体征是不可靠的，并且在更晚期的疾病中可见。诊断肝纤维化的新成像技术是可靠和准确的，包括磁共振弹性成像和US弹性成像（一维瞬态弹性成像和点剪切波弹性成像或声辐射力脉冲成像）。目前正在研究多种其他技术用于肝纤维化的非侵入性诊断，包括磁共振弥散加权成像、肝胆对比增强和灌注; CT灌注、部分细胞外间隙技术和双能量、对比增强超声、多种模式的纹理分析、定量标测和直接分子成像探针。努力推进肝纤维化的无创成像评估将有助于早期诊断和改善患者监测，以防止进展为肝硬化及其并发症。
Hepatic fibrosis is potentially reversible, however early diagnosis is necessary for treatment in order to halt progression to cirrhosis and development of complications including portal hypertension and hepatocellular carcinoma. Morphologic signs of cirrhosis on ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI) alone are unreliable and are seen with more advanced disease. Newer imaging techniques to diagnose liver fibrosis are reliable and accurate, and include magnetic resonance elastography and US elastography (1 dimensional transient elastography and point shear wave elastography or acoustic radiation force impulse imaging). Research is ongoing with multiple other techniques for the noninvasive diagnosis of hepatic fibrosis, including MRI with diffusion weighted imaging, hepatobiliary contrast enhancement, and perfusion; CT using perfusion, fractional extracellular space techniques, and dual energy, contrast-enhanced US, texture analysis in multiple modalities, quantitative mapping, and direct molecular imaging probes. Efforts to advance the noninvasive imaging assessment of hepatic fibrosis will facilitate earlier diagnosis and improved patient monitoring with the goal of preventing the progression to cirrhosis and its complications.
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