Role of trabecular microarchitecture in the formation, accumulation, and morphology of microdamage in human cancellous bone.
Role of trabecular microarchitecture in the formation, accumulation, and morphology of microdamage in human cancellous bone.
复制标题
DOI：
10.1002/jor.21448
复制
发表时间：
2011-11
影响因子：
2.8
通讯作者：
Vashishth, Deepak
中科院分区：
文献类型：
--
作者：
Karim, Lamya;Vashishth, Deepak
微损伤形态和积聚的改变通常归因于重塑受损，但也可能是微损伤的起始和传播的变化所致。这种改变与高代谢活性的松质骨和大量的骨质量变化有关。本研究探讨骨小梁微结构在人松质骨微损伤的形态和累积中的作用。取不同年龄和骨体积分数(BV/TV)的骨小梁，分为高BV/TV组和低BV/TV组。样品受到无载荷或单轴压缩至0.6%(屈服前)或1.1%(屈服后)应变。微损伤用醋酸铀酰铅染色，标本通过微计算机断层扫描进行成像，以定量微损伤并确定其三维形态。高BV/TV供者比低BV/TV供者有更大的产后压力和更强的韧性。高BV/TV比低BV/TV骨在屈服后而不是屈服前的载荷下微损伤较小。两种加载条件下的微损伤均与微结构和BV/TV显著相关，但关键的预测因子是结构模型指数(SMI)。随着SMI的增加(更多的小梁棒)，微损伤形态变得类似于裂纹。因此，低的BV/TV和增加的SMI通过改变起始点对微损伤在骨中的积累有很大的影响。
Alterations in microdamage morphology and accumulation are typically attributed to impaired remodeling, but may also result from changes in microdamage initiation and propagation. Such alterations are relevant for cancellous bone with high metabolic activity and numerous bone quality changes. This study investigates the role of trabecular microarchitecture on morphology and accumulation of microdamage in human cancellous bone. Trabecular bone cores from donors of varying ages and bone volume fraction (BV/TV) were separated into high and low BV/TV groups. Samples were subjected to no load or uniaxial compression to 0.6% (pre-yield) or 1.1% (post-yield) strain. Microdamage was stained with lead uranyl acetate and specimens were imaged via microcomputed tomography to quantify microdamage and determine its morphology in three-dimensions (3D). Donors with high BV/TV had greater post yield strain and were tougher than low BV/TV donors. High BV/TV bone had less microdamage than low BV/TV bone under post- but not pre-yield loading. Microdamage under both loading conditions showed significant correlations with microarchitecture and BV/TV, but the key predictor was structure model index (SMI). As SMI increased (more trabecular rods), microdamage morphology became crack-like. Thus, low BV/TV and increased SMI have strong influences on microdamage accumulation in bone through altered initiation.
登录
查看更多内容
影响因子：
4.1
作者：
Ding, M;Hvid, I
通讯作者：
Hvid, I
影响因子：
120.7
作者：
CUMMINGS, SR;BLACK, DM;VOGT, TM
通讯作者：
VOGT, TM
影响因子：
4.1
作者：
GROTE, HJ;AMLING, M;DELLING, G
通讯作者：
DELLING, G
影响因子：
4.3
作者：
Judex, Stefan;Boyd, Steve;Rubin, Clinton
通讯作者：
Rubin, Clinton
影响因子：
4.1
作者：
Parfitt, AM
通讯作者：
Parfitt, AM