Descriptive epidemiology of persistent diarrhoea among young children in rural northern India.
Descriptive epidemiology of persistent diarrhoea among young children in rural northern India.
复制标题
印度北部农村幼儿持续性腹泻的描述性流行病学。
DOI：
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发表时间：
1989
影响因子：
11.1
通讯作者：
J. Kaper
中科院分区：
文献类型：
--
作者：
M. K. Bhan;Nita Bhandari;Sunil Sazawal;J. Clemens;P. Raj;M. M. Levine;J. Kaper
为了确定印度北部农村地区持续性腹泻的描述性流行病学，通过每周家访，对963名0-71个月大的儿童进行了为期12个月的前瞻性随访。在0-71个月的儿童中，持续性腹泻的发生率为6.3 / 100个儿童年，在0-11个月的儿童中最高（31 / 100个儿童年）。该疾病的发病率没有显著的性别差异，急性和持续性腹泻的总体季节性分布相似。腹泻症状的持续与较高的初始平均大便频率（P < 0.01）和随便总血通过（P < 0.001）显著相关。持续腹泻是儿童生命最初2年的一个重要问题。46.4%的持续性发作和55.4%的急性发作在发病初期分离出已确定的肠道病原体。在持续发作期间分离的病原体包括产肠毒素的大肠杆菌（ETEC 9.3%）、沙门氏菌（4.7%）、弯曲杆菌（4.7%）、志贺氏菌（2.3%）、溶组织内阿米巴（2.3%）和轮状病毒（2.3%）。在急性腹泻发作期间也分离出类似比例的这些病原体。在7%的持续性发作和5%的急性发作中分离出多种病原体。表现出聚集性粘附（EAEC-A）的大肠杆菌在持续发作中比急性发作更常见（34.9%对12.3%）（P < 0.01），并且EAEC-A的初始粪便排泄与腹泻发作的持续存在显著相关。
In order to determine the descriptive epidemiology of persistent diarrhoea in rural northern India, a cohort of 963 children aged 0-71 months was followed prospectively for 12 months through weekly household visits. The incidence of persistent diarrhoea was 6.3 per 100 child-years among those aged 0-71 months, and was highest (31 per 100 child-years) among those aged 0-11 months. There were no significant sex-related differences in the incidence of the disease, and the overall seasonal distribution of acute and persistent diarrhoea was similar. The persistence of diarrhoeal symptoms was significantly correlated with a higher initial mean stool frequency (P less than 0.01) and passage of gross blood with stools (P less than 0.001). Persistent diarrhoea was an important problem among children during the first 2 years of life. Established enteric pathogens were isolated during the initial illness in 46.4% of persistent and 55.4% of acute episodes. Pathogens isolated during persistent episodes included enterotoxigenic Escherichia coli (ETEC 9.3%), Salmonella spp. (4.7%), as well as campylobacter (4.7%), Shigella spp. (2.3%), Entamoeba histolytica (2.3%), and rotavirus (2.3%). Similar proportions of these pathogens were isolated also during episodes of acute diarrhoea. Multiple pathogens were isolated in 7% of the persistent and 5% of the acute episodes. E. coli that manifested aggregative adherence (EAEC-A) was more common (34.9% versus 12.3%) in persistent than acute episodes (P less than 0.01), and initial faecal excretion of EAEC-A was significantly associated with the persistence of a diarrhoeal episode.
影响因子：
6.4
作者：
VIAL, PA;ROBINSBROWNE, R;LEVINE, MM
通讯作者：
LEVINE, MM
用于识别 O157:H7 肠出血性大肠杆菌和导致出血性结肠炎和溶血性尿毒症综合征的其他血清型的 DNA 探针。
DOI：
10.1093/infdis/156.1.175
发表时间：
1987
期刊：
The Journal of infectious diseases
影响因子：
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作者：
Levine,MM;Xu,JG;Kaper,JB;Lior,H;Prado,V;Tall,B;Nataro,J;Karch,H;Wachsmuth,K
通讯作者：
Wachsmuth,K