Release of Interleukin 2 and Gamma Interferon by Peripheral Mononuclear Cells in Human Schistosoma mansoni Infection Normalizes after Chemotherapy
Release of Interleukin 2 and Gamma Interferon by Peripheral Mononuclear Cells in Human Schistosoma mansoni Infection Normalizes after Chemotherapy
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人曼氏血吸虫感染的外周单核细胞释放白细胞介素 2 和γ干扰素，化疗后恢复正常
DOI：
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发表时间：
1989
影响因子：
3.7
通讯作者：
H. Feldmeier
中科院分区：
文献类型：
--
作者：
K. Zwingenberger;E. Irschick;J. G. Vergetti;A. Dacal;R. Janssen;U. Bienzle;C. Huber;H. Feldmeier
本文测定了肝、脾、肠血吸虫病患者有丝分裂原和抗原驱动细胞培养上清液中白细胞介素2(IL-2)和干扰素-γ的水平。皮肤反应性测试使用了一组八种召回抗原。将结果与未感染的当地对照组进行比较。两组血吸虫病患者治疗前IL-2活性均降低。在不到三分之一的患者中，血吸虫抗原激发了可检测到的IL-2活性。在肝脾病例中，干扰素-γ的产生减少得更严重，尤其是在抗CD3单抗刺激后。经吡喹酮治疗后，肠道血吸虫病患者IL-2和干扰素-γ活性在3个月内恢复正常，肝脾患者在6个月内恢复正常。体内迟发性超敏反应试验的结果与体外产生淋巴因子的结果相似。总之，有证据表明，淋巴因子的产生和皮肤对召回抗原的反应性受到严重的、非抗原特异性的抑制。抗寄生虫化疗可以在细胞因子水平逆转细胞介导的免疫反应的损害。
Interleukin 2(IL‐2) and gamma interferon (IFN‐γ) were determined in supernatantsof mitogen and antigen‐driven cell cultures from patients with hepatosplenic or intestinal schistosomiasis. Skin reactivity was tested using a panel of eight recall antigens. Results were compared with those of uninfected local controls. In both schistosomiasis groups, IL‐2 activity was reduced before treatment. In less than one third of the patients, schistosomal antigens elicited detectable IL‐2 activity. IFN‐γ production was reduced more severely in hapatosplenic cases, in particular after stimulation by anti‐CD3 monoclonal antibodies. After anti‐schistosomal therapy with praziquantel, mitogen‐induced IL‐2 and IFN‐γ activities became normal within 3 months in intestinal schistosomiasis, and within 6 months in the hepatosplenic patient group. Results of in vivo delayed‐type hypersensitivity tests paralleled those of in vitro lymphokine production. In conclusion, evidence is presented for severe, antigen‐unspecific suppression of lymphokine production and skin reactivity against recall antigens. Anti‐parasitic chemotherapy is shown to reverse the impairment of cell‐mediated immune responses at the cytokine level.
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影响因子：
15.9
作者：
AMENTO, EP;BHAN, AK;KRANE, SM
通讯作者：
KRANE, SM
影响因子：
15.9
作者：
GRANSTEIN, RD;MURPHY, GF;AMENTO, EP
通讯作者：
AMENTO, EP
血吸虫病中的成纤维细胞刺激。
DOI：
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发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Wyler,DJ;Ehrlich,HP;Postlethwaite,AE;Raghow,R;Murphy,MM
通讯作者：
Murphy,MM
血吸虫病中卵肉芽肿衍生的成纤维细胞生长因子的间充质靶细胞特异性。
DOI：
10.1093/infdis/155.4.728
发表时间：
1987
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Wyler,DJ;Prakash,S;Libby,P
通讯作者：
Libby,P
干扰素-γ增强肿瘤坏死因子细胞受体的表达。
DOI：
--
发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Tsujimoto,M;Yip,YK;Vilcek,J
通讯作者：
Vilcek,J