Does cognitive behavioral therapy for anxiety disorders assist the discontinuation of benzodiazepines among patients with anxiety disorders? A systematic review and meta-analysis.
Does cognitive behavioral therapy for anxiety disorders assist the discontinuation of benzodiazepines among patients with anxiety disorders? A systematic review and meta-analysis.
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DOI：
10.1111/pcn.13195
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发表时间：
2021-04
影响因子：
11.9
通讯作者：
Takaesu Y
中科院分区：
文献类型：
--
作者：
Takeshima M;Otsubo T;Funada D;Murakami M;Usami T;Maeda Y;Yamamoto T;Matsumoto T;Shimane T;Aoki Y;Otowa T;Tani M;Yamanaka G;Sakai Y;Murao T;Inada K;Yamada H;Kikuchi T;Sasaki T;Watanabe N;Mishima K;Takaesu Y
不推荐长期使用苯二氮卓类药物(BZD)治疗焦虑症。认知行为疗法(CBT)是焦虑症患者停用BZD的有效治疗选择。这项系统性综述和荟萃分析试图阐明CBT对于焦虑症患者停用BZD抗焦虑药是否有效。这项研究已在PROSPERO注册(注册号：CRD42019125263)。2018年12月对主要电子数据库进行了文献检索。本综述包括三个随机对照试验，并进行荟萃分析。在短期(分配后3个 月；需要治疗的数量：3.2，95%可信区间：2.1~7.1；风险比：1.96，95%CI：1.2~2.98，P=0.002，3项研究)和长期(分配后6~12个 月；需要治疗的数量：2.8，95%CI：1.9~5.3)；风险比：2.16，95%CI：1.41~3.32，P=0.0004，三项研究)。CBT对停用BZD抗焦虑药可能是有效的，无论是在分配后的短期还是长期。有必要进行更大样本量的进一步研究，以得出关于CBT在焦虑症患者中停用BZD抗焦虑药物的有效性和安全性的明确结论。
Long‐term use of benzodiazepines (BZD) is not recommended for the treatment of anxiety disorders. Cognitive behavioral therapy (CBT) is an effective treatment option for discontinuation of BZD in patients with anxiety disorders. This systematic review and meta‐analysis sought to clarify whether CBT is effective for discontinuing BZD anxiolytics in patients with anxiety disorders. This study was preregistered with PROSPERO (registration number: CRD42019125263). A literature search of major electronic databases was conducted in December 2018. Three randomized controlled trials were included in this review, and meta‐analyses were performed. The proportion of discontinuing BZD anxiolytics was significantly higher in the CBT plus gradual tapering group than in the gradual tapering alone group, both in the short term (3 months after allocation; number needed to treat: 3.2, 95% confidence interval [CI]: 2.1 to 7.1; risk ratio: 1.96, 95%CI: 1.29 to 2.98, P = 0.002, three studies) and long term (6 to 12 months after allocation; number needed to treat: 2.8, 95%CI: 1.9 to 5.3; risk ratio: 2.16, 95%CI: 1.41 to 3.32, P = 0.0004, three studies). CBT may be effective for discontinuing BZD anxiolytics, both in the short term and in the long term after the allocation. Further studies with larger sample sizes are necessary to draw definitive conclusions regarding the efficacy and safety of CBT for discontinuing BZD anxiolytics in patients with anxiety disorders.
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影响因子：
15.8
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
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通讯作者：
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作者：
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通讯作者：
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