Regulation of Sexual Commitment and Gametocytogenesis in Malaria Parasites.
Regulation of Sexual Commitment and Gametocytogenesis in Malaria Parasites.
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DOI：
10.1146/annurev-micro-090817-062712
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发表时间：
2018-09-08
影响因子：
10.5
通讯作者：
Llinás M
中科院分区：
文献类型：
--
作者：
Josling GA;Williamson KC;Llinás M
疟疾寄生虫从无性血液阶段到配子体的性别分化是生命周期的重要组成部分，因为配子体是蚊子宿主所采取的形式。由于这一过程对于传播给蚊子的重要性，配子体发生是治疗干预的一个非常有吸引力的目标。本文综述的主题是近年来在阐明这一重要分化过程的分子机制方面取得的相当大的进展。特别是，一些关键的转录因子和表观遗传调节因子已经成为调节承诺的关键因素。这些因素的识别使我们能够比以往任何时候都更好地了解发生在性发育承诺之前和期间的事件，并为新的治疗干预提供了可能。
Sexual differentiation of malaria parasites from the asexual blood stage into gametocytes is an essential part of the life cycle, as gametocytes are the form that is taken up by the mosquito host. Because of the essentiality of this process for transmission to the mosquito, gametocytogenesis is an extremely attractive target for therapeutic interventions. The subject of this review is the considerable progress that has been made in recent years in elucidating the molecular mechanisms governing this important differentiation process. In particular, a number of critical transcription factors and epigenetic regulators have emerged as crucial elements in the regulation of commitment. The identification of these factors has allowed us to understand better than ever before the events occurring prior to and during commitment to sexual development and offers potential for new therapeutic interventions.
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DOI：
10.1126/science.aan6042
发表时间：
2018-03-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Filarsky M;Fraschka SA;Niederwieser I;Brancucci NMB;Carrington E;Carrió E;Moes S;Jenoe P;Bártfai R;Voss TS
通讯作者：
Voss TS
影响因子：
14.8
作者：
Brancucci, Nicolas M. B.;Goldowitz, Ilana;Marti, Matthias
通讯作者：
Marti, Matthias
影响因子：
2.4
作者：
Buckling, A;Ranford-Cartwright, LC;Read, AF
通讯作者：
Read, AF
影响因子：
3.5
作者：
Gissot, M;Refour, P;Vaquero, C
通讯作者：
Vaquero, C
影响因子：
1.5
作者：
Eksi, S;Haile, Y;Williamson, KC
通讯作者：
Williamson, KC