Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis.
Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis.
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DOI：
10.1016/j.cmet.2010.09.013
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发表时间：
2010-11-03
期刊：
影响因子：
29
通讯作者：
Lowell BB
中科院分区：
文献类型：
--
作者：
Kong D;Vong L;Parton LE;Ye C;Tong Q;Hu X;Choi B;Brüning JC;Lowell BB
血糖水平受到严格控制，这一过程被认为主要是由外周机制(β细胞分泌胰岛素，以及胰岛素对肌肉、脂肪和肝脏的作用)协调的。大脑也扮演着重要的角色，尽管定义不那么明确。大脑中的神经元亚群由葡萄糖兴奋；在许多情况下，这涉及到ATP介导的KATP通道的关闭。为了理解这一点的相关性，我们正在操纵葡萄糖兴奋神经元中的葡萄糖感应。在本研究中，我们证明了下丘脑外侧区表达MCH的神经元的葡萄糖兴奋是由KATP通道介导的，受到UCP2(一种减少ATP产生的线粒体蛋白)的负调节，并且MCH神经元的葡萄糖感知在调节葡萄糖稳态中起着重要作用。总而言之，葡萄糖兴奋的神经元很可能在调节血糖方面发挥以前意想不到的关键作用。
Blood glucose levels are tightly controlled, a process thought to be orchestrated primarily by peripheral mechanisms (insulin secretion by β-cells, and insulin action on muscle, fat and liver). The brain also plays an important, albeit less well-defined role. Subsets of neurons in the brain are excited by glucose; in many cases this involves ATP-mediated closure of KATP channels. To understand the relevance of this, we are manipulating glucose sensing within glucose-excited neurons. In the present study, we demonstrate that glucose excitation of MCH-expressing neurons in the lateral hypothalamus is mediated by KATP channels, is negatively regulated by UCP2 (a mitochondrial protein that reduces ATP production), and that glucose sensing by MCH neurons plays an important role in regulating glucose homeostasis. Combined, the glucose-excited neurons are likely to play key, previously unexpected roles in regulating blood glucose.
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影响因子：
16.2
作者：
Dhillon, H;Zigman, JM;Lowelll, BB
通讯作者：
Lowelll, BB
DOI：
10.1111/j.1748-1716.2008.01922.x
发表时间：
2009-01
期刊：
Acta physiologica (Oxford, England)
影响因子：
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影响因子：
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