Prevalence and predictors of hair pulling disorder and excoriation disorder in Tourette syndrome.
Prevalence and predictors of hair pulling disorder and excoriation disorder in Tourette syndrome.
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DOI：
10.1007/s00787-017-1074-z
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发表时间：
2018-05
影响因子：
6.4
通讯作者：
Tourette Association of America International Consortium for Genetics
中科院分区：
文献类型：
--
作者：
Greenberg E;Tung ES;Gauvin C;Osiecki L;Yang KG;Curley E;Essa A;Illmann C;Sandor P;Dion Y;Lyon GJ;King RA;Darrow S;Hirschtritt ME;Budman CL;Grados M;Pauls DL;Keuthen NJ;Mathews CA;Scharf JM;Tourette Association of America International Consortium for Genetics
拔毛/拔毛障碍(HPD)和拔毛/挑皮障碍(SPD)是儿童时期发病的、以身体为中心的重复行为，被认为与强迫症(OCD)和抽动秽语综合征(TS)具有相同的遗传易感性和潜在的病理生理。我们试图确定DSM-5、HPD和SPD在TS患者中的患病率，并确定与它们与TS共同发病最相关的临床因素。参与者包括从TS专科诊所招募的811名TS患者进行多中心遗传学研究。患者使用标准化的、有效的半结构化访谈进行评估。HPD和SPD的诊断是使用有效的自我报告问卷确定的。计算HPD/SPD患病率，并用回归模型评估临床预测因素。分别有3.8%和13.0%的TS患者符合DSM-5的HPD和SPD标准。在单变量分析中，女性、强迫症、抽搐和强迫症的严重程度与HPD和/或SPD有关。在多变量分析中，只有一生中最严重的运动抽搐严重程度仍然与HPD显著相关。女性、强迫症、多动症和运动性抽搐的严重程度仍然与SPD独立相关。这是第一次使用半结构诊断仪器在TS样本中检查HPD和SPD患病率的研究。TS患者中HPD和SPD的患病率，以及它们与抽动严重程度增加和共生OCD的相关性，表明临床医生应该筛查TS儿童和相关疾病的HPD/SPD，特别是在女性和共生OCD儿童中。这项研究还有助于为后续关于HPD/SPD危险因素、病理生理学和治疗模式的研究奠定基础。
Trichotillomania/hair pulling disorder (HPD) and excoriation/skin picking disorder (SPD) are childhood-onset, body-focused repetitive behaviors that are thought to share genetic susceptibility and underlying pathophysiology with obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). We sought to determine the prevalence of DSM-5 HPD and SPD in TS patients, and to identify clinical factors most associated with their co-morbidity with TS. Participants included 811 TS patients recruited from TS specialty clinics for a multi-center genetic study. Patients were assessed using standardized, validated semi-structured interviews. HPD and SPD diagnoses were determined using a validated self-report questionnaire. HPD/SPD prevalence rates were calculated, and clinical predictors were evaluated using regression modeling. 3.8% and 13.0% of TS patients met DSM-5 criteria for HPD and SPD, respectively. In univariable analyses, female sex, OCD, and both tic and obsessive-compulsive severity were among those associated with HPD and/or SPD. In multivariable analyses, only lifetime worst-ever motor tic severity remained significantly associated with HPD. Female sex, co-occurring OCD, ADHD and motor tic severity remained independently associated with SPD. This is the first study to examine HPD and SPD prevalence in a TS sample using semi-structured diagnostic instruments. The prevalence of HPD and SPD in TS patients, and their association with increased tic severity and co-occurring OCD, suggests that clinicians should screen children with TS and related disorders for HPD/SPD, particularly in females and in those with co-occurring OCD. This study also helps set a foundation for subsequent research regarding HPD/SPD risk factors, pathophysiology, and treatment models.
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DOI：
10.1097/00004583-200005000-00009
发表时间：
2000-05-01
影响因子：
13.3
作者：
Coffey, BJ;Biederman, J;Kim, GS
通讯作者：
Kim, GS
影响因子：
1.9
作者：
Coffey, BJ;Miguel, EC;Jenike, MA
通讯作者：
Jenike, MA
影响因子：
3.8
作者：
Freeman, RD;Fast, DG;Sandor, P
通讯作者：
Sandor, P
影响因子：
11.3
作者：
Darrow SM;Illmann C;Gauvin C;Osiecki L;Egan CA;Greenberg E;Eckfield M;Hirschtritt ME;Pauls DL;Batterson JR;Berlin CM;Malaty IA;Woods DW;Scharf JM;Mathews CA
通讯作者：
Mathews CA
影响因子：
6.9
作者：
Bienvenu, O. J.;Samuels, J. F.;Nestadt, G.
通讯作者：
Nestadt, G.