Mixed functional microarchitectures for orientation selectivity in the mouse primary visual cortex.

Mixed functional microarchitectures for orientation selectivity in the mouse primary visual cortex.
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DOI:
10.1038/ncomms13210
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发表时间:
2016-10-21
影响因子:
16.6
通讯作者:
Ohki, Kenichi
Ohki, Kenichi
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Kondo, Satoru;Yoshida, Takashi;Ohki, Kenichi

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微柱是大脑皮层结构中最小的解剖学模块,但它是否作为皮层处理的功能单位仍存在争议。在啮齿动物初级视皮层(V1),具有不同偏好取向的神经元以盐和胡椒的方式水平混合,但没有检查垂直功能组织。在这项研究中,我们发现,具有类似的方向偏好的神经元是弱的,但显着的集群垂直在一个短的长度和水平的规模的一个微型柱。有趣的是,垂直聚类仅在一部分微柱中发现,其他微柱由具有各种取向偏好的神经元组成。因此,小鼠V1是具有不同程度的取向相似性的垂直神经元簇的混合物,这可能是大脑大小和保持类似调谐的神经元的垂直簇至少在簇的子集中之间的折衷。初级视觉皮层神经元显示大多是盐和胡椒排列的方向偏好沿着水平皮质轴。在这里,作者表明,一个重要的子集的微柱,一个细胞宽阵列的细胞排列沿着垂直轴,显示出类似的方向调整偏好。
A minicolumn is the smallest anatomical module in the cortical architecture, but it is still in debate whether it serves as functional units for cortical processing. In the rodent primary visual cortex (V1), neurons with different preferred orientations are mixed horizontally in a salt and pepper manner, but vertical functional organization was not examined. In this study, we found that neurons with similar orientation preference are weakly but significantly clustered vertically in a short length and horizontally in the scale of a minicolumn. Interestingly, the vertical clustering is found only in a part of minicolumns, and others are composed of neurons with a variety of orientation preferences. Thus, the mouse V1 is a mixture of vertical clusters of neurons with various degrees of orientation similarity, which may be the compromise between the brain size and keeping the vertical clusters of similarly tuned neurons at least in a subset of clusters. Primary visual cortical neurons display mostly a salt and pepper arrangement of orientation preferences along the horizontal cortical axis. Here the authors show that a significant subset of minicolumns, one-cell wide arrays of cells arranged along the vertical axis, show similar orientation tuning preferences.
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