Development and evolution of the human neocortex.

Development and evolution of the human neocortex.
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DOI:
10.1016/j.cell.2011.06.030
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发表时间:
2011-07-08
期刊:
影响因子:
64.5
通讯作者:
Kriegstein AR
Kriegstein AR
中科院分区:
生物学1区
文献类型:
--
作者:
Lui JH;Hansen DV;Kriegstein AR

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哺乳动物大脑的大小和表面积被认为是智力的关键决定因素。近期研究表明,人类脑回状新皮质的发育涉及一系列神经干细胞和过渡放大细胞,这些细胞形成了室管膜下区外层(OSVZ),即脑室上皮外的一个增殖区域。我们探讨了OSVZ内细胞的增殖如何通过增加神经元数量和改变迁移神经元的轨迹来使新皮质扩张。将这些特征与其他哺乳动物物种以及小鼠新皮质已知的分子调节因子相关联,揭示了这一发育过程在进化中是如何出现的。
The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show that development of the gyrated human neocortex involves a lineage of neural stem and transit-amplifying cells that forms the outer subventricular zone (OSVZ), a proliferative region outside the ventricular epithelium. We discuss how proliferation of cells within the OSVZ expands the neocortex by increasing neuron number and modifying the trajectory of migrating neurons. Relating these features to other mammalian species and known molecular regulators of the mouse neocortex suggests how this developmental process could have emerged in evolution.
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