Particulate matter and the airway epithelium: the special case of the underground?
Particulate matter and the airway epithelium: the special case of the underground?
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DOI：
10.1183/16000617.0066-2019
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发表时间：
2019-09-30
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影响因子：
--
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中科院分区：
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--
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空气颗粒物(PM)是过早死亡和心肺疾病的主要驱动因素，与哮喘和慢性阻塞性肺疾病、特发性肺纤维化和肺癌的恶化有关。呼吸道上皮作为PM沉积的主要部位，对PM的影响和最初的反应至关重要。PM发挥作用的一个关键机制是产生活性氧(ROS)，在暴露的上皮细胞中诱导抗氧化剂和炎症反应。然而，人们对PM的影响所知的很大一部分是基于对城市空气中颗粒物的研究。来自地下铁路的PM在成分上与城市PM有很大的不同，富含与车轮、钢轨和刹车磨损以及电气弧光和部件磨损有关的金属，这赋予了地下PM强大的ROS发电能力。此外，在上皮细胞中，地下PM似乎比城市PM更容易发炎，但缺乏对接触者的影响的研究，特别是那些有潜在健康状况的人。本文综述了颗粒物对呼吸道上皮细胞的影响，地下颗粒物的影响与城市颗粒物的不同，以及对通勤者和地铁工人的潜在健康影响和缓解策略。与地面相比，地下铁路中空气中的颗粒物更加集中，金属含量也更高。围绕着这可能意味着对暴露在空气中的通勤者和工作人员的影响的证据是有限的，也是不一致的。Http://bit.ly/2KtcorT
Airborne particulate matter (PM) is a leading driver of premature mortality and cardiopulmonary morbidity, associated with exacerbations of asthma and chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and lung cancer. The airway epithelium, as the principal site of PM deposition, is critical to the effects of, and initial response to, PM. A key mechanism by which PM exerts its effects is the generation of reactive oxygen species (ROS), inducing antioxidant and inflammatory responses in exposed epithelial cells. However, much of what is known about the effects of PM is based on research using particulates from urban air. PM from underground railways is compositionally highly distinct from urban PM, being rich in metals associated with wheel, rail and brake wear and electrical arcing and component wear, which endows underground PM with potent ROS-generating capacity. In addition, underground PM appears to be more inflammogenic than urban PM in epithelial cells, but there is a lack of research into effects on exposed individuals, especially those with underlying health conditions. This review summarises current knowledge about the effects of PM on the airway epithelium, how the effects of underground PM may be different to urban PM and the potential health consequences and mitigation strategies for commuters and workers in underground railways. Airborne particulate matter in underground railways is much more concentrated and metal-rich than that found above ground. The evidence surrounding what this might mean for effects on the airways of exposed commuters and staff is limited and inconsistent. http://bit.ly/2KtcorT
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影响因子：
32.4
作者：
Bronner DN;Abuaita BH;Chen X;Fitzgerald KA;Nuñez G;He Y;Yin XM;O'Riordan MX
通讯作者：
O'Riordan MX
自噬对于超细颗粒诱导的气道上皮炎症和粘液过度产生至关重要
影响因子：
13.3
作者：
Chen, Zhi-Hua;Wu, Yin-Fang;Shen, Hua-Hao
通讯作者：
Shen, Hua-Hao
DOI：
10.1165/rcmb.2011-0031oc
发表时间：
2011-11-01
影响因子：
6.4
作者：
Hackett, Tillie-Louise;Singhera, Gurpreet K.;Knight, Darryl A.
通讯作者：
Knight, Darryl A.
影响因子：
6.3
作者：
Bigert, Carolina;Klerdal, Kristina;Gustavsson, Per
通讯作者：
Gustavsson, Per
影响因子：
168.9
作者：
Guarnieri, Michael;Balmes, John R.
通讯作者：
Balmes, John R.