Retinopathy of prematurity and brain damage in the very preterm newborn.
Retinopathy of prematurity and brain damage in the very preterm newborn.
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DOI：
10.1016/j.jaapos.2014.01.014
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发表时间：
2014-06
期刊：
影响因子：
1.6
通讯作者：
Weaver, Grey
中科院分区：
文献类型：
--
作者：
Allred, Elizabeth N.;Capone, Antonio, Jr.;Fraioli, Anthony;Dammann, Olaf;Droste, Patrick;Duker, Jay;Gise, Robert;Kuban, Karl;Leviton, Alan;O'Shea, T. Michael;Paneth, Nigel;Petersen, Robert;Trese, Michael;Stoessel, Kathleen;Vanderveen, Deborah;Wallace, David K.;Weaver, Grey
为了解释为什么早产儿视网膜病变（ROP）的早产新生儿似乎是在大脑结构和功能异常的风险增加。共有1，085名小于28周妊娠出生的儿童进行了有临床指征的视网膜检查，并在2岁矫正年龄时进行了发育评估。ROP类别和大脑异常之间的关系进行了探讨，使用逻辑回归模型调整潜在的混杂因素。173名患有严重ROP（定义为阈值前ROP（n = 146）或更严重（n = 27））的儿童比没有ROP的同龄人更有可能患有脑超声病变或脑瘫。他们有大约两倍的可能性有非常低的贝利量表得分。在调整ROP和脑部疾病共同的风险因素后，发生严重ROP的婴儿仅发生低Bayley量表的风险增加。在阈值前ROP的儿童中，麻醉暴露与低Bayley量表无关。ROP与脑部疾病的部分但非全部关联可以用常见的风险因素来解释。大多数与ROP相关的非常低的Bayley量表的风险增加可能不是暴露于麻醉剂的结果。
To explain why very preterm newborns who develop retinopathy of prematurity (ROP) appear to be at increased risk of abnormalities of both brain structure and function. A total of 1,085 children born at <28 weeks’ gestation had clinically indicated retinal examinations and had a developmental assessment at 2 years corrected age. Relationships between ROP categories and brain abnormalities were explored using logistic regression models with adjustment for potential confounders. The 173 children who had severe ROP, defined as prethreshold ROP (n = 146) or worse (n = 27) were somewhat more likely than their peers without ROP to have brain ultrasound lesions or cerebral palsy. They were approximately twice as likely to have very low Bayley Scales scores. After adjusting for risk factors common to both ROP and brain disorders, infants who developed severe ROP were at increased risk of low Bayley Scales only. Among children with prethreshold ROP, exposure to anesthesia was not associated with low Bayley Scales. Some but not all of the association of ROP with brain disorders can be explained by common risk factors. Most of the increased risks of very low Bayley Scales associated with ROP are probably not a consequence of exposure to anesthetic agents.
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影响因子：
2.3
作者：
Kuban, Karl;Adler, Ira;Leviton, Alan
通讯作者：
Leviton, Alan
影响因子：
2.5
作者：
Leviton, Alan;Kuban, Karl C. K.;Paneth, Nigel
通讯作者：
Paneth, Nigel
影响因子：
4.1
作者：
HUNGERFORD, J;STEWART, A;HOPE, P
通讯作者：
HOPE, P
影响因子：
8.3
作者：
Back, Stephen A.;Riddle, Art;McClure, Melissa M.
通讯作者：
McClure, Melissa M.
DOI：
10.1136/adc.2002.023374
发表时间：
2004-05-01
影响因子：
4.4
作者：
Cooke, RWI;Foulder-Hughes, L;Clarke, D
通讯作者：
Clarke, D