Natural killer cells in asthma.
Natural killer cells in asthma.
复制标题
DOI：
10.3389/fimmu.2013.00159
复制
发表时间：
2013
影响因子：
7.3
通讯作者：
Forsythe P
中科院分区：
文献类型：
--
作者：
Karimi K;Forsythe P
过去几十年来，全球哮喘的患病率、发病率和死亡率急剧增加，显然需要确定新的有效治疗和预防策略。尽管肺部存在大量 NK 细胞，并且它们能够产生多种免疫调节介质，但 NK 细胞作为过敏性气道疾病治疗靶点的潜力在很大程度上被忽视了。事实上，IgE 通过 FcγRIII 起作用，可以激活 NK 细胞，导致细胞因子/趋化因子的产生，这意味着 NK 细胞可能有助于 IgE 介导的过敏反应。事实上，目前的证据表明 NK 细胞可以在致敏和持续炎症过程中促进过敏性气道反应。在动物模型中，在抗原攻击后，在肺部观察到 NK 细胞增加，并且在免疫抑制过敏性气道炎症之前细胞被耗尽。此外，在哮喘患者中，NK 细胞表型发生改变，可能有助于促进促炎 Th2 型环境。相反，驱动 NK 细胞分泌 IFN-γ 表型可以减少动物模型中过敏性气道反应的特征。然而，我们对驱动肺部 NK 细胞不同亚群和功能表型发育的信号了解有限，因此 NK 细胞在过敏性气道中的作用和治疗潜力仍不清楚。在这里，我们回顾了 NK 细胞在过敏性气道疾病中的潜在不同作用，确定了当前知识的差距，并讨论了调节 NK 细胞功能作为哮喘治疗策略的潜力。
The worldwide prevalence, morbidity, and mortality of asthma have dramatically increased over the last few decades and there is a clear need to identify new effective therapeutic and prophylactic strategies. Despite high numbers of NK cells in the lung and their ability to generate a variety of immunomodulatory mediators, the potential of NK cells as therapeutic targets in allergic airway disease has been largely overlooked. The fact that IgE, acting through FcγRIII, can activate NK cells resulting in cytokine/chemokine production implies that NK cells may contribute to IgE-mediated allergic responses. Indeed, current evidence suggests that NK cells can promote allergic airway responses during sensitization and ongoing inflammation. In animal models, increased NK cells are observed in the lung following antigen challenge and depletion of the cells before immunization inhibits allergic airway inflammation. Moreover, in asthmatics, NK cell phenotype is altered and may contribute to the promotion of a pro-inflammatory Th2-type environment. Conversely, driving NK cells toward an IFN-γ-secreting phenotype can reduce features of the allergic airway response in animal models. However, we have limited knowledge of the signals that drive the development of distinct subsets and functional phenotypes of NK cells in the lung and thus the role and therapeutic potential of NK cells in the allergic airway remains unclear. Here we review the potentially diverse role of NK cells in allergic airway disease, identify gaps in current knowledge, and discuss the potential of modulating NK cell function as a treatment strategy in asthma.
登录
查看更多内容
影响因子：
15.3
作者：
Ashkar, A A;Di Santo, J P;Croy, B A
通讯作者：
Croy, B A
DOI：
10.1016/j.bbmt.2009.01.019
发表时间：
2009-07
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Gill S;Olson JA;Negrin RS
通讯作者：
Negrin RS
影响因子：
15.9
作者：
Eberlein, Jens;Nguyen, Tom T.;Homann, Dirk
通讯作者：
Homann, Dirk
影响因子：
4.4
作者：
Arase, N;Arase, H;Saito, T
通讯作者：
Saito, T
影响因子：
2.4
作者：
Harata, G.;He, F.;Yausi, H.
通讯作者：
Yausi, H.