Role of ginsenosides in reactive oxygen species-mediated anticancer therapy.
Role of ginsenosides in reactive oxygen species-mediated anticancer therapy.
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人参皂苷在活性氧介导的抗癌治疗中的作用
DOI：
10.18632/oncotarget.23407
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发表时间：
2018-01-05
期刊：
影响因子：
--
通讯作者：
Sun H
中科院分区：
文献类型：
--
作者：
Sodrul IMD;Wang C;Chen X;Du J;Sun H
癌症仍然是一个全球性的公共卫生问题，是大多数国家的主要死亡原因。人参作为延年益寿的灵丹妙药在世界各地已经使用了几个世纪。作为草本植物之王，人参作为一种新的治疗选择，无论是单独使用还是与其他药物成分结合使用，都被广泛接受为癌症治疗的补充和替代药物。人参皂苷是人参的主要药理活性成分，已被证明具有多种药物作用，包括突出的抗癌活性。本文就人参皂苷在活性氧（ROS）介导的抗癌治疗中的作用进行综述。为进一步改进和开展临床前和临床试验，使其成功发展成为潜在的抗癌药物提供新的思路。人参及其衍生物/代谢物人参皂苷对治疗各种类型的癌症有有益的作用。人参皂苷的ros介导的抗癌活性的机制取决于所涉及的特定类型的癌细胞。人参皂苷可能通过抑制肿瘤起始的抗氧化作用抑制癌细胞增殖，并通过激活AMPK、MEK、ASK-1/JNK、ESR2-NCF1-ROS、er依赖性PI3K/Akt/Nrf2、P53-CHOP、ROS-JNK自噬和/或抑制PI3K/Akt信号通路等多种信号通路，通过产生ROS促进肿瘤进展、促进血管生成、侵袭转移，诱导细胞凋亡、凋亡或自噬。这些多重作用而不是单一作用可能在人参皂苷作为一种成功的抗癌药物中发挥关键作用。
Cancer is still a global public health problem, which is the leading cause of death in most countries. Ginseng has been used for centuries all over the world as a panacea that promotes longevity. As the king of herb plants, ginseng holds great promise as a new treatment option which is used either by itself or in combination with other medicinal ingredients that is widely accepted as complementary and alternative medicine in cancer therapy. Ginsenosides, the major pharmacologically active ingredients of ginseng, have been shown to have multiple medicinal effects including prominent anticancer activity. The purpose of this review is to give our perspective about the roles of ginsenosides in reactive oxygen species (ROS)-mediated anticancer therapy. Additionally, to provide new sheds light for further improvement and carry out pre-clinical and clinical trials to develop it successfully into a potential anticancer agent. Panax herbs and their derivate/metabolites ginsenosides exert beneficial effects for treating various types of cancers. The mechanism of ROS-mediated anticancer activities of ginsenosides varies depending on the specific type of cancer cells involved. Ginsenosides may suppress cancer cell proliferation through anti-oxidation on tumor initiation and induce apoptosis, paraptosis or autophagy via generation of ROS on tumor progression, promotion, angiogenesis, invasion and metastasis by various signaling pathways e.g., activation of AMPK, MEK, ASK-1/JNK, ESR2-NCF1-ROS, ER-dependent PI3K/Akt/Nrf2, P53-CHOP, ROS-JNK-autophagy, and/or inhibition of PI3K/Akt signaling pathways. These multiple effects rather than a single may play a crucial role in emerging ginsenosides as a successful anticancer drug.
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