Exhaled breath condensate biomarkers in critically ill, mechanically ventilated patients.
Exhaled breath condensate biomarkers in critically ill, mechanically ventilated patients.
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DOI：
10.1088/1752-7163/abc235
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发表时间：
2020-11-12
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
作者：
肺炎是危重机械通气（CIMV）患者的重大风险。肺炎的诊断通常需要临床医生指导的诊断和临床评分系统的组合。呼出气冷凝液（EBC）可以安全无创地从CIMV患者中收集。EBC中的数百种生物标志物与急性疾病状态相关，包括肺炎。我们评估了CIMV患者EBC中的细胞因子，并假设这些生物标志物与肺炎、败血症和死亡的疾病严重程度相关。EBC IL-2水平与胸片严重程度评分相关（比值比= 1.68; 95%置信区间= 1.09 - 2.60; P = 0.02）。EBC TNF-α水平也与肺炎相关（比值比= 3.20; 95%置信区间= 1.19 - 8.65; P = 0.02）。这项研究的技术和结果可能对所有机械通气患者有用。
Pneumonia is a significant risk for critically ill, mechanically ventilated (CIMV) patients. Diagnosis of pneumonia generally requires a combination of clinician-guided diagnoses and clinical scoring systems. Exhaled breath condensate (EBC) can be safely collected non-invasively from CIMV patients. Hundreds of biomarkers in EBC are associated with acute disease states, including pneumonia. We evaluated cytokines in EBC from CIMV patients and hypothesized that these biomarkers would correlate with disease severity in pneumonia, sepsis, and death. EBC IL-2 levels were associated with chest radiograph severity scores (odds ratio = 1.68; 95% confidence interval = 1.09 – 2.60; P = 0.02). EBC TNF-α levels were also associated with pneumonia (odds ratio = 3.20; 95% confidence interval = 1.19 – 8.65; P = 0.02). The techniques and results from this study may be useful for all mechanically ventilated patients.
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