Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process.
Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process.
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DOI：
10.1002/dvdy.22092
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发表时间：
2009-10
影响因子：
2.5
通讯作者：
Mina, Mina
中科院分区：
文献类型：
--
作者：
Balic, Anamaria;Adams, Douglas;Mina, Mina
缺乏Prx1和Prx2的小鼠在下颌骨表现出严重的异常。我们的分析表明，Prx基因产物的完全缺失导致下颌突生长异常，早在E10.5就明显存在，这与内侧区域间质存活的变化有关。内侧和外侧区域基因表达的变化与表达eHand的内侧区域间质亚群的逐渐丧失有关。我们的分析还表明，Prx基因产物对于梅克尔软骨尾端和吻端软骨细胞的软骨形成和终分化的启动和维持是必需的。Prx1/Prx2双突变体的下颌突融合是由加速骨化引起的。这些观察结果表明，在下颌形态发生过程中，Prx基因产物发挥了多种作用，包括细胞存活、区域特异性软骨细胞终末分化和成骨。
Mice lacking both Prx1 and Prx2 display severe abnormalities in the mandible. Our analysis showed that complete loss of Prx gene products leads to growth abnormalities in the mandibular processes evident as early as E10.5 associated with changes in the survival of the mesenchyme in the medial region. Changes in the gene expression in the medial and lateral regions were related to gradual loss of a subpopulation of mesenchyme in the medial region expressing eHand. Our analysis also showed that Prx gene products are required for the initiation and maintenance of chondrogenesis and terminal differentiation of the chondrocytes in the caudal and rostral ends of Meckel’s cartilage. The fusion of the mandibular processes in the Prx1/Prx2 double mutants is caused by accelerated ossification. These observations together show that during mandibular morphogenesis Prx gene products play multiple roles including the cell survival, the region-specific terminal differentiation of Meckelian chondrocytes and osteogenesis.
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