Elevated serum iron is a potent biomarker for spirometric resistance to cigarette smoke among Japanese males: the Takahata study.
Elevated serum iron is a potent biomarker for spirometric resistance to cigarette smoke among Japanese males: the Takahata study.
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DOI：
10.1371/journal.pone.0074020
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kubota I
中科院分区：
文献类型：
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作者：
Shibata Y;Inoue S;Igarashi A;Yamauchi K;Abe S;Aida Y;Nunomiya K;Sato M;Nakano H;Sato K;Watanabe T;Konta T;Ueno Y;Kato T;Kayama T;Kubota I
慢性阻塞性肺病是有大量吸烟习惯的老年人的常见残疾。与易吸烟人群相比，肺功能随着接触香烟烟雾时间的延长而恶化，而老年人的肺功能并未受损。然而，迄今为止，尚未对这一耐药吸烟人群的特征进行调查。我们的目的是确定尽管吸烟但仍保持肺部健康的个体的生物标志物。对 2004 年至 2006 年在日本高畠参加社区年度健康检查的 3,257 名受试者进行了血液采样和肺活量测定。我们选择了 117 名老年吸烟者（年龄≥70，布林克曼指数≥600，吸烟年数≥30）。 “耐吸烟”组符合以下标准：FEV1/FVC ≥0.7，且 FEV1% 预测≥80。 2009 年，对 147 名当前吸烟的男性进行了肺活量测定重新评估。与不耐药组相比，耐药组的基线血清铁 (sFe) 水平较高。在 sFe 水平较低的男性受试者中，FEV1/FVC 降低。这些肺活量测量值与男性的 sFe 水平呈正相关。多元线性回归分析显示，sFe 水平可预测肺量测定值，独立于其他临床因素。此外，sFe 水平可预测 FEV1 下降。血清铁水平可能是个体肺活量测定对香烟烟雾敏感性的生物标志物。
Chronic obstructive pulmonary disease is a common disability among elderly subjects with a heavy cigarette smoking habit. In contrast to the population that is susceptible to smoking, in whom pulmonary function worsens with the length of exposure to cigarette smoke, there are elderly individuals whose pulmonary function is not impaired. However, to date, the characteristics of this resistant smoking population have not been investigated. We aimed to identify a biomarker in individuals in whom lung health is maintained despite smoking. Blood sampling and spirometry were performed on 3,257 subjects who participated in a community-based annual health check in Takahata, Japan, from 2004 to 2006. We selected 117 elderly smokers (age ≥70, Brinkman index ≥600, smoking years ≥30). The ‘smoking resistant’ group met the following criteria: FEV1/FVC ≥0.7, and FEV1%predicted ≥80. Spirometry was re-evaluated in 147 male, current smokers in 2009. Baseline serum iron (sFe) levels were higher in the smoke resistant group compared with the non-resistant group. In those with low sFe levels, FEV1/FVC was reduced in male subjects. These spirometric measures were positively associated with sFe levels in men. Multiple linear regression analysis revealed that sFe levels were predictive for spirometric values, independent of other clinical factors. In addition, sFe levels were predictive for a decline in FEV1.Serum iron levels may be a biomarker for the spirometric susceptibility of individuals to cigarette smoke.
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影响因子：
3.6
作者：
Aida Y;Shibata Y;Osaka D;Abe S;Inoue S;Fukuzaki K;Tokairin Y;Igarashi A;Yamauchi K;Nemoto T;Nunomiya K;Kishi H;Sato M;Watanabe T;Konta T;Kawata S;Kato T;Kubota I
通讯作者：
Kubota I
影响因子：
3.6
作者：
Sato M;Shibata Y;Abe S;Inoue S;Igarashi A;Yamauchi K;Aida Y;Kishi H;Nunomiya K;Nakano H;Sato K;Watanabe T;Konta T;Ueno Y;Kato T;Kayama T;Kubota I
通讯作者：
Kubota I
DOI：
10.1164/rccm.200802-334oc
发表时间：
2008-12-01
影响因子：
24.7
作者：
Ghio, Andrew J.;Hilborn, Elizabeth D.;Pinkerton, Kent E.
通讯作者：
Pinkerton, Kent E.
影响因子：
3.5
作者：
Cho, Michael H.;Castaldi, Peter J.;Silverman, Edwin K.
通讯作者：
Silverman, Edwin K.
影响因子：
30.8
作者：
通讯作者：
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