Retrospective analysis of the relationship between decline in FEV(1) and abdominal circumference in male smokers: the Takahata study.
Retrospective analysis of the relationship between decline in FEV(1) and abdominal circumference in male smokers: the Takahata study.
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DOI：
10.7150/ijms.5003
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发表时间：
2013
影响因子：
3.6
通讯作者：
Kubota I
中科院分区：
文献类型：
--
作者：
Sato M;Shibata Y;Abe S;Inoue S;Igarashi A;Yamauchi K;Aida Y;Kishi H;Nunomiya K;Nakano H;Sato K;Watanabe T;Konta T;Ueno Y;Kato T;Kayama T;Kubota I
背景：据报道，代谢综合征（Mets）与慢性阻塞性肺病（COPD）有关。然而，腹围 (AC) 与 FEV1 下降之间的关系尚未阐明。我们的目的是调查目前男性吸烟者之间的这种关系。方法：对年龄≥ 40 岁的受试者 (n = 3,257) 进行肺量测定，这些受试者于 2004 年至 2006 年期间参加了日本高畠市的社区年度健康检查（访视 1）。 2009 年，对 147 名男性当前吸烟者进行了肺活量测定和 AC 评估（访问 2）。 Mets 的诊断是基于久山研究中使用的标准。结果：AC 和肺活量参数（例如预测用力肺活量 (FVC) 百分比、1 秒内用力呼气量百分比 (FEV1) 和 FEV1/FVC）之间没有观察到显着关系。然而，FEV1 的下降与 AC 显着相关。多变量 Logistic 回归分析显示，AC 是 FEV1 下降的一个重要判别因素，与年龄、Brinkman 指数和从访视 1 到访视 2 的体重指数变化无关。在访视 2 时，患有 Mets 的受试者 (n=17) 的 FEV1 下降的发生率高于没有 Mets 的受试者。尽管在患有或不患有 Met 的受试者之间，预测 FVC %、预测 FEV1 % 或 FEV1/FVC 没有差异，但患有 Met 的受试者中 FEV1 下降率显着高于不患有 Mes 的受试者。结论：这项回顾性分析表明，测量 AC 可能有助于区分 FEV1 下降的男性吸烟者。
Background:Metabolic syndrome (Mets) is reportedly associated with chronic obstructive pulmonary disease (COPD). However, the relationship between abdominal circumference (AC) and decline in FEV1 has not been elucidated. We aimed to investigate this relationship among male current smokers. Methods:Spirometry was performed on subjects (n = 3,257) ≥ 40 years of age, who participated in a community-based annual health check in Takahata, Japan, from 2004 through 2006 (visit 1). Spirometry was re-evaluated, and AC was assessed in 147 of the male current smokers in 2009 (visit 2). The diagnosis of Mets was based on the criteria used in the Hisayama Study. Results:No significant relationships were observed between AC and spirometric parameters such as % predicted forced vital capacity (FVC), % predicted forced expiratory volume in 1 s (FEV1) and FEV1/FVC. However, decline in FEV1 was significantly correlated with AC. Multivariate logistic regression analysis showed that AC was a significant discriminating factor for decline in FEV1, independently of age, Brinkman index and change in body mass index from visit 1 to visit 2. At visit 2, there was a greater prevalence of decline in FEV1 among subjects with Mets (n=17) than among those without Mets. Although there were no differences in % predicted FVC, % predicted FEV1 or FEV1/FVC between subjects with or without Mets, the rate of decline in FEV1 was significantly greater in subjects with Mets than in those without. Conclusions:This retrospective analysis suggested that measuring AC may be useful for discriminating male smokers who show a decline in FEV1.
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影响因子：
3.6
作者：
Aida Y;Shibata Y;Osaka D;Abe S;Inoue S;Fukuzaki K;Tokairin Y;Igarashi A;Yamauchi K;Nemoto T;Nunomiya K;Kishi H;Sato M;Watanabe T;Konta T;Kawata S;Kato T;Kubota I
通讯作者：
Kubota I
影响因子：
24.3
作者：
Mannino, D. M.;Thorn, D.;Holguin, F.
通讯作者：
Holguin, F.
影响因子：
4.4
作者：
Nishiyama, Satoshi;Watanabe, Tetsu;Kubota, Isao
通讯作者：
Kubota, Isao
影响因子：
3.6
作者：
Shibata Y;Watanabe T;Osaka D;Abe S;Inoue S;Tokairin Y;Igarashi A;Yamauchi K;Kimura T;Kishi H;Aida Y;Nunomiya K;Nemoto T;Sato M;Konta T;Kawata S;Kato T;Kayama T;Kubota I
通讯作者：
Kubota I
影响因子：
15.9
作者：
Kasahara, Y;Tuder, RM;Voelkel, NF
通讯作者：
Voelkel, NF