The relationship between serum uric acid and spirometric values in participants in a health check: the Takahata study.
The relationship between serum uric acid and spirometric values in participants in a health check: the Takahata study.
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DOI：
10.7150/ijms.8.470
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发表时间：
2011
影响因子：
3.6
通讯作者：
Kubota I
中科院分区：
文献类型：
--
作者：
Aida Y;Shibata Y;Osaka D;Abe S;Inoue S;Fukuzaki K;Tokairin Y;Igarashi A;Yamauchi K;Nemoto T;Nunomiya K;Kishi H;Sato M;Watanabe T;Konta T;Kawata S;Kato T;Kubota I
背景：组织缺氧诱导三磷酸腺苷降解，导致尿酸（UA）产生。据报道，与对照组相比，慢性阻塞性肺疾病（COPD）患者的血清UA（sUA）水平较高。然而，在一般人群中，sUA水平和肺功能测定之间的关系尚未得到详细研究。研究方法：本研究入组了2004年和2005年在日本Takahata参加过基于社区的年度健康检查的40岁或以上受试者（n = 2，917）。这些受试者进行肺功能测定，测量血压，并采集血液样本。结果：男性sUA水平显著高于女性。女性用力肺活量预测值百分比[FVC %预测值]（r = -0.13）和1秒用力呼气量[FEV1%预测值]（r = -0.118）与sUA水平呈负相关，但男性不相关。单因素回归分析显示，男性sUA水平与年龄、体重指数（BMI）、酒精摄入量、平均血压（BP）和血清肌酐（sCr）显著相关。在女性中，年龄、BMI、平均BP、血红蛋白A1 c、sCr、FVC %预测值和FEV1%预测值与sUA水平显著相关。多元线性回归分析显示，对于两种性别，FVC %预测值和FEV1%预测值可预测sUA水平，与其他临床参数无关。有肺限制的受试者比无肺限制的受试者有更高的sUA水平。此外，中度和重度气流受限受试者的sUA水平高于无气流受限或轻度气流受限受试者。结论：在一般人群中，FVC %预测值和FEV1%预测值与sUA水平显著相关。
Background: Tissue hypoxia induces the degradation of adenosine triphosphate, resulting in the production of uric acid (UA). Patients with chronic obstructive pulmonary disease (COPD) have been reported to have high serum levels of UA (sUA), compared with control subjects. However, the relationship between sUA levels and spirometric measures has not been investigated in detail in a general population. Methods: Subjects aged 40 years or older (n = 2,917), who had participated in a community-based annual health check in Takahata, Japan, in 2004 and 2005, were enrolled in the study. These subjects performed spirometry, their blood pressure was measured, and a blood sample was taken. Results: sUA levels were significantly higher in males than in females. Percent predicted forced vital capacity [FVC %predicted] (r = -0.13) and forced expiratory volume in 1 s [FEV1 %predicted] (r = -0.118) were inversely correlated with sUA levels in females but not in males. Univariate regression analysis indicated that age, body mass index (BMI), ethanol intake, mean blood pressure (BP), and serum creatinine (sCr) were significantly associated with sUA levels in males. In females, age, BMI, mean BP, hemoglobin A1c, sCr, FVC %predicted, and FEV1 %predicted were significantly associated with sUA levels. Multiple linear regression analysis showed that for both genders, FVC %predicted and FEV1 %predicted were predictive for sUA levels, independently of the other clinical parameters. Subjects with lung restriction had higher sUA levels than subjects without lung restriction. In addition, subjects with moderate and severe airflow limitation had higher sUA levels than subjects without airflow limitation or those with mild airflow limitation. Conclusion: FVC %predicted and FEV1 %predicted were significantly associated with sUA levels in a general population.
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影响因子：
4.5
作者：
Conen D;Wietlisbach V;Bovet P;Shamlaye C;Riesen W;Paccaud F;Burnier M
通讯作者：
Burnier M
影响因子：
6.1
作者：
Garcia-Larsen, V.;Chinn, S.;Rona, R. J.
通讯作者：
Rona, R. J.
影响因子：
3.6
作者：
Jeha, S
通讯作者：
Jeha, S
影响因子：
10.4
作者：
CROSS, CE;VANDERVLIET, A;HALLIWELL, B
通讯作者：
HALLIWELL, B
影响因子：
3
作者：
Kaneko, Kazunari;Taniguchi, Naho;Nozu, Kandai
通讯作者：
Nozu, Kandai