Traumatic brain injury and the pathways to cerebral tau accumulation.
Traumatic brain injury and the pathways to cerebral tau accumulation.
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外伤性脑损伤与脑tau积聚的途径。
DOI：
10.3389/fneur.2023.1239653
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发表时间：
2023
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
--
作者：
Tau是一种蛋白质，因其对大脑的潜在负面影响而得到国家主流的认可。本文简要介绍了tau的结构及其正常的生理功能，包括在冬眠和动情周期中的变化。有许多途径参与tau的磷酸化，包括糖尿病、中风、阿尔茨海默病(AD)、脑损伤、衰老和药物使用。这些过程的共同机制与观察到的轻度和重复轻度创伤性脑损伤(TBI)的变化有关。Tau的磷酸化是向病理发展的一部分，但tau聚集和繁殖的能力也被提及。总结tau的功能和功能失调的作用可以帮助我们加深对这种复杂蛋白的理解，改善我们对有脑外伤病史的患者的护理，并导致开发出预防或逆转tau介导的神经变性的治疗干预措施。
Tau is a protein that has received national mainstream recognition for its potential negative impact to the brain. This review succinctly provides information on the structure of tau and its normal physiological functions, including in hibernation and changes throughout the estrus cycle. There are many pathways involved in phosphorylating tau including diabetes, stroke, Alzheimer’s disease (AD), brain injury, aging, and drug use. The common mechanisms for these processes are put into context with changes observed in mild and repetitive mild traumatic brain injury (TBI). The phosphorylation of tau is a part of the progression to pathology, but the ability for tau to aggregate and propagate is also addressed. Summarizing both the functional and dysfunctional roles of tau can help advance our understanding of this complex protein, improve our care for individuals with a history of TBI, and lead to development of therapeutic interventions to prevent or reverse tau-mediated neurodegeneration.
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影响因子：
3.4
作者：
Luo J;Nguyen A;Villeda S;Zhang H;Ding Z;Lindsey D;Bieri G;Castellano JM;Beaupre GS;Wyss-Coray T
通讯作者：
Wyss-Coray T
影响因子：
3.2
作者：
Bieniek KF;Cairns NJ;Crary JF;Dickson DW;Folkerth RD;Keene CD;Litvan I;Perl DP;Stein TD;Vonsattel JP;Stewart W;Dams-O'Connor K;Gordon WA;Tripodis Y;Alvarez VE;Mez J;Alosco ML;McKee AC;TBI/CTE Research Group
通讯作者：
TBI/CTE Research Group
影响因子：
7.8
作者：
Caccamo A;Magrì A;Medina DX;Wisely EV;López-Aranda MF;Silva AJ;Oddo S
通讯作者：
Oddo S
影响因子：
16.6
作者：
Ambadipudi S;Biernat J;Riedel D;Mandelkow E;Zweckstetter M
通讯作者：
Zweckstetter M
影响因子：
1.9
作者：
Bazarian, Jeffrey J.;Zemlan, Frank P.;Stigbrand, Torgney
通讯作者：
Stigbrand, Torgney