"Hot cross bun" is a potential imaging marker for the severity of cerebellar ataxia in MSA-C.
"Hot cross bun" is a potential imaging marker for the severity of cerebellar ataxia in MSA-C.
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“热十字面包”是 MSA-C 小脑共济失调严重程度的潜在影像学标志物
DOI：
10.1038/s41531-021-00159-w
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发表时间：
2021-02-15
期刊：
影响因子：
--
通讯作者：
Wang Q
中科院分区：
文献类型：
--
作者：
Zhu S;Deng B;Huang Z;Chang Z;Li H;Liu H;Huang Y;Pan Y;Wang Y;Chao YX;Chan LL;Wu YR;Tan EK;Wang Q
目的探讨多系统萎缩（MSA）患者“热十字面包”征（HCB）与疾病严重程度的相关性。我们招募了可能和可能患有帕金森综合征（MSA-P）或小脑共济失调（MSA-C）亚型的患者。收集MSA-C和MSA-P病例的临床和影像学特征并进行比较。斯皮尔曼检验用于评估HCBs与其他变量之间的相关性。曲线估计和一般线性回归进行评估HCB和共济失调评估和评级量表（SARA）之间的关系。采用统一多系统萎缩评定量表（UMSRS）IV评估疾病严重程度。使用多项有序逻辑回归来确认该疾病的残疾可能性增加。招募了81名患有HCB的MSA，包括50名MSA-C和31名MSA-P。我们证明了HCB的严重程度与MSA-C中的SARA评分呈线性正相关。多项有序逻辑回归检验显示，HCB等级的增加可能与MSA疾病严重程度的残疾可能性增加有关，尤其是在患有小脑共济失调亚型的患者中。我们证明HCB是小脑共济失调严重程度的潜在影像学标记物。HCB分级的增加可能与MSA-C患者残疾的可能性增加相关，但与MSA-P病例无关，这表明它可能是中国MSA-C患者疾病进展的有用影像学指标。
To evaluate the correlation between “hot cross bun” sign (HCBs) and disease severity in multiple system atrophy (MSA). We recruited patients with probable and possible MSA with parkinsonism (MSA-P) or the cerebellar ataxia (MSA-C) subtypes. Clinical and imaging characteristics were collected and comparison was performed between MSA-C and MSA-P cases. Spearman test was used to evaluate the correlation between HCBs and other variables. Curve estimate and general linear regression was performed to evaluate the relationship between HCBs and the Scale for Assessment and Rating of Ataxia (SARA). Unified Multiple System Atrophy Rating Scale (UMSARS) IV was used to assess the severity of disease. Multinomial ordered logistic regression was used to confirm the increased likelihood of disability for the disease. Eighty-one MSA with HCBs comprising of 50 MSA-C and 31 MSA-P were recruited. We demonstrated that the severity of HCBs showed a positive linear correlation with SARA scores in MSA-C. Multinomial ordered logistic regression test revealed that the increase in the HCBs grade may be associated with an increased likelihood of disability for the disease severity in MSA, especially in those with cerebellar ataxia subtype. We demonstrated that HCBs is a potential imaging marker for the severity of cerebellar ataxia. The increase in the HCBs grade may be associated with an increased likelihood of disability in MSA-C, but not MSA-P cases, suggesting that it may be a useful imaging indicator for disease progression in Chinese patients with MSA-C.
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影响因子：
8.6
作者：
Stankovic, Iva;Krismer, Florian;Jesic, Aleksandar;Antonini, Angelo;Benke, Thomas;Brown, Richard G.;Burn, David J.;Holton, Janice L.;Kaufmann, Horacio;Kostic, Vladimir S.;Ling, Helen;Meissner, Wassilios G.;Poewe, Werner;Semnic, Marija;Seppi, Klaus;Takeda, Atsushi;Weintraub, Daniel;Wenning, Gregor K.
通讯作者：
Wenning, Gregor K.
影响因子：
5.2
作者：
Seki, Morinobu;Seppi, Klaus;Scherfler, Christoph
通讯作者：
Scherfler, Christoph
影响因子：
5.1
作者：
Carli, G.;Caminiti, S. P.;Perani, D.
通讯作者：
Perani, D.
影响因子：
14.5
作者：
O'Sullivan, S. S.;Massey, L. A.;Lees, A. J.
通讯作者：
Lees, A. J.
影响因子：
7.4
作者：
Xu, Jinghui;Fu, Xiaodi;Xu, Yunqi
通讯作者：
Xu, Yunqi