Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group.
Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group.
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DOI：
10.1002/mds.25880
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发表时间：
2014-06
影响因子：
8.6
通讯作者：
Wenning, Gregor K.
中科院分区：
文献类型：
--
作者：
Stankovic, Iva;Krismer, Florian;Jesic, Aleksandar;Antonini, Angelo;Benke, Thomas;Brown, Richard G.;Burn, David J.;Holton, Janice L.;Kaufmann, Horacio;Kostic, Vladimir S.;Ling, Helen;Meissner, Wassilios G.;Poewe, Werner;Semnic, Marija;Seppi, Klaus;Takeda, Atsushi;Weintraub, Daniel;Wenning, Gregor K.
多系统萎缩的共识诊断标准将痴呆视为非支持性特征，尽管新出现的证据表明认知障碍是该疾病的组成部分。多系统萎缩中的认知障碍发生在从轻度单域缺陷到多域损伤的广泛范围内，甚至在某些情况下发生坦率的痴呆。额叶执行功能障碍是最常见的表现，而记忆和视觉空间功能也可能受损。影像学和神经病理学研究结果支持这一概念，即认知功能障碍的MSA起源于纹状体额区传入神经阻滞与额外的贡献，从内在的皮质变性和小脑病理。基于一个全面的循证综述，我们在这里提出了未来的研究途径，最终可能导致诊断标准的认知功能障碍和痴呆症与多系统萎缩。
Consensus diagnostic criteria for multiple system atrophy consider dementia as a non-supporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal-executive dysfunction is the most common presentation, while memory and visuospatial functions may also be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidence-based review we here propose future avenues of research that may ultimately lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy.
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